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Type: Conference paper
Title: Bone fracture and bone fracture repair
Author: Fazzalari, N.
Citation: Bone Quality Seminars, 2011 / vol.22, iss.6, pp.2003-2006
Publisher: Springer London Ltd
Publisher Place: Sweetapple House Catteshall Road Godalming England GU7 3DJ
Issue Date: 2011
ISSN: 0937-941X
Conference Name: Bone Quality Seminars (Osteoporosis International)
Statement of
N. L. Fazzalari
Abstract: Fracture healing is a multistage repair process that involves complex, well-orchestrated steps initiated in response to tissue injury. The early upregulation of IL-6, osteoprotegerin (OPG), VEGF, and BMPs indicates a central role for these factors in the initiation of cartilage and periosteal woven bone formation. In both callus fracture repair and stress fracture repair, the RANKL/OPG ratio is initially reduced, but peaks earlier in stress fracture healing than callus fracture healing. Though the understanding of the biological processes and molecular signals that coordinate fracture repair has advanced, the cause of variability observed in fracture repair is poorly understood.
Keywords: Fracture; fracture repair; microdamage; stress; fracture
Rights: © International Osteoporosis Foundation and National Osteoporosis Foundation 2011
RMID: 0020108727
DOI: 10.1007/s00198-011-1611-4
Appears in Collections:Medical Sciences publications

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