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dc.contributor.authorFazzalari, N.en
dc.identifier.citationBone Quality Seminars, 2011 / vol.22, iss.6, pp.2003-2006en
dc.description.abstractFracture healing is a multistage repair process that involves complex, well-orchestrated steps initiated in response to tissue injury. The early upregulation of IL-6, osteoprotegerin (OPG), VEGF, and BMPs indicates a central role for these factors in the initiation of cartilage and periosteal woven bone formation. In both callus fracture repair and stress fracture repair, the RANKL/OPG ratio is initially reduced, but peaks earlier in stress fracture healing than callus fracture healing. Though the understanding of the biological processes and molecular signals that coordinate fracture repair has advanced, the cause of variability observed in fracture repair is poorly understood.en
dc.description.statementofresponsibilityN. L. Fazzalarien
dc.publisherSpringer London Ltden
dc.rights© International Osteoporosis Foundation and National Osteoporosis Foundation 2011en
dc.subjectFracture; fracture repair; microdamage; stress; fractureen
dc.titleBone fracture and bone fracture repairen
dc.typeConference paperen
dc.contributor.conferenceBone Quality Seminars (Osteoporosis International)en
dc.publisher.placeSweetapple House Catteshall Road Godalming England GU7 3DJen
pubs.library.collectionMedical Sciences publicationsen
Appears in Collections:Medical Sciences publications

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