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Type: Journal article
Title: Aquaporin-4 expression after experimental contusional injury in an ovine impact-acceleration head injury model
Author: Finnie, J.
Blumbergs, P.
Manavis, J.
Citation: Journal of Clinical Neuroscience, 2011; 18(7):947-950
Publisher: Churchill Livingstone
Issue Date: 2011
ISSN: 0967-5868
Statement of
John W. Finnie, Peter C. Blumbergs and Jim Manavis
Abstract: Cerebral contusions are one of the principal lesions of traumatic brain injury and the attendant oedema formation contributes substantially to the clinicopathological manifestations. While it is now recognised that the membrane channel protein aquaporin-4 (AQP-4) plays a major role in the development and resolution of cerebral oedema, assessments of its expression in and around contusions have produced conflicting results. We used an ovine impact-acceleration model of closed head injury to examine contusion-related AQP-4 expression and found that there was a heterogeneous AQP-4 response within contusions, with some astrocytes being nonviable and immunonegative, while others showed increased AQP-4 expression. Pericontusional astrocytes in the penumbra region generally showed more robust AQP-4 immunopositivity than intracontusional glia. Thus, manipulation of AQP-4 expression could have therapeutic applications in controlling cerebral oedema associated with contusions.
Keywords: Astrocytes
Brain Edema
Brain Injuries
Head Injuries, Closed
Disease Models, Animal
Aquaporin 4
Rights: © 2011 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.jocn.2010.11.010
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