Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Aquaporin-4 expression after experimental contusional injury in an ovine impact-acceleration head injury model|
|Citation:||Journal of Clinical Neuroscience, 2011; 18(7):947-950|
|John W. Finnie, Peter C. Blumbergs and Jim Manavis|
|Abstract:||Cerebral contusions are one of the principal lesions of traumatic brain injury and the attendant oedema formation contributes substantially to the clinicopathological manifestations. While it is now recognised that the membrane channel protein aquaporin-4 (AQP-4) plays a major role in the development and resolution of cerebral oedema, assessments of its expression in and around contusions have produced conflicting results. We used an ovine impact-acceleration model of closed head injury to examine contusion-related AQP-4 expression and found that there was a heterogeneous AQP-4 response within contusions, with some astrocytes being nonviable and immunonegative, while others showed increased AQP-4 expression. Pericontusional astrocytes in the penumbra region generally showed more robust AQP-4 immunopositivity than intracontusional glia. Thus, manipulation of AQP-4 expression could have therapeutic applications in controlling cerebral oedema associated with contusions.|
Head Injuries, Closed
Disease Models, Animal
|Rights:||© 2011 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Agriculture, Food and Wine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.