Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72242
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Single-nucleotide polymorphisms in the KDR gene in pregnancies complicated by gestational hypertensive disorders and small-for-gestational-age infants
Author: Andraweera, P.
Dekker, G.
Thompson, S.
Roberts, C.
Citation: Reproductive Sciences, 2012; 19(5):547-554
Publisher: Sage Publications
Issue Date: 2012
ISSN: 1933-7191
1933-7205
Statement of
Responsibility: 
Prabha H. Andraweera, Gustaaf A. Dekker, Steven D. Thompson and Claire T. Roberts
Abstract: INTRODUCTION: Pregnancies complicated by preeclampsia and small-for-gestational-age (SGA) infants share placental vascular abnormalities and both disorders confer increased risk of later life coronary artery disease. Kinase insert domain receptor (KDR) is the main receptor for vascular endothelial growth factor A, a potent angiogenic factor which regulates the development of the placental vasculature. Two polymorphisms in KDR (-604T/C and Val297Ile) are known to be associated with coronary artery disease. We investigated the association of these polymorphisms with preeclampsia, gestational hypertension, and SGA infants. METHOD: Nulliparous pregnant women, their partners, and infants were recruited to a prospective cohort study (n ¼ 1169). Doppler ultrasound of the uterine and umbilical arteries was performed at 20 weeks of gestation. Preeclampsia, gestational hypertension, and SGA were defined according to international guidelines. DNA extracted from peripheral venous or cord blood was genotyped using the Sequenom MassARRAY system. Multivariable logistic regression was used to compare the odds for the pregnancy complications between the genotype groups adjusting for potential confounders. RESULTS: Among 937 Caucasian pregnancies, 427 (45.6%) were uncomplicated, 75 (8.0%) developed preeclampsia, 102 (10.9%) developed gestational hypertension, and 72 (7.7%) had SGA infants in the absence of maternal hypertensive disease. Paternal and neonatal KDR-604T/C was associated with preeclampsia (adjusted odds ratio [aOR] 1.6, 95% confidence interval [CI] 1.0-3.0 and aOR 2.2, 95% CI 1.0-4.4), SGA (aOR 1.9, 95% CI 1.1-3.3 and aOR 2.2, 95% CI 1.2-3.9), and SGA with abnormal Doppler (aOR 2.7, 95% CI 1.2-5.9 and aOR 3.2, 95% CI 1.2-5.9). CONCLUSION: Paternal and neonatal carriage of the KDR-604T/C polymorphism is associated with the risk of preeclampsia and SGA infants.
Keywords: KDR; polymorphism; preeclampsia; small-for-gestational-age infants
Rights: Copyright © 2012 by Society fo Gynecologic Investigation
RMID: 0020118745
DOI: 10.1177/1933719111428520
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.