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|Title:||The effect of the GABAB receptor agonist baclofen on liquid and solid gastric emptying in mice|
|Citation:||European Journal of Pharmacology, 2003; 470(1-2):95-97|
|Publisher:||Elsevier Science BV|
|Abstract:||The effect of the GABA(B) receptor agonist baclofen, a potential treatment for gastroesophageal reflux, on gastric emptying has not been determined. The effect of 1-4 mg/kg baclofen on liquid and solid gastric emptying in mice was evaluated by noninvasive [13C] breath tests. Baclofen accelerated gastric emptying of solids but delayed emptying of liquid, suggesting that it may have differential effects on proximal and distal stomach emptying.|
|Keywords:||Animals; Mice, Inbred C57BL; Mice; Baclofen; Receptors, GABA-B; GABA Agonists; Gastric Emptying; Female; GABA-B Receptor Agonists|
|Appears in Collections:||Paediatrics publications|
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