Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7227
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Type: Journal article
Title: The effect of the GABAB receptor agonist baclofen on liquid and solid gastric emptying in mice
Author: Symonds, E.
Butler, R.
Omari, T.
Citation: European Journal of Pharmacology, 2003; 470(1-2):95-97
Publisher: Elsevier Science BV
Issue Date: 2003
ISSN: 0014-2999
1879-0712
Abstract: The effect of the GABA(B) receptor agonist baclofen, a potential treatment for gastroesophageal reflux, on gastric emptying has not been determined. The effect of 1-4 mg/kg baclofen on liquid and solid gastric emptying in mice was evaluated by noninvasive [13C] breath tests. Baclofen accelerated gastric emptying of solids but delayed emptying of liquid, suggesting that it may have differential effects on proximal and distal stomach emptying.
Keywords: Animals; Mice, Inbred C57BL; Mice; Baclofen; Receptors, GABA-B; GABA Agonists; Gastric Emptying; Female; GABA-B Receptor Agonists
RMID: 0020030159
DOI: 10.1016/S0014-2999(03)01779-5
Appears in Collections:Paediatrics publications

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