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https://hdl.handle.net/2440/72322
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dc.contributor.author | Wheeler, A. | - |
dc.contributor.author | Beltrame, J. | - |
dc.contributor.author | Tucker, G. | - |
dc.contributor.author | Air, T. | - |
dc.contributor.author | Ling, L. | - |
dc.contributor.author | Schrader, G. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Australian and New Zealand Journal of Psychiatry, 2012; 46(7):669-675 | - |
dc.identifier.issn | 0004-8674 | - |
dc.identifier.issn | 1440-1614 | - |
dc.identifier.uri | http://hdl.handle.net/2440/72322 | - |
dc.description.abstract | Objective: Symptoms of depression are highly prevalent and persistent following myocardial infarction (MI). Whether depression is a risk factor for long-term mortality following MI remains controversial. The present study aimed to determine whether depression during hospitalisation for acute MI (AMI) predicted 5-year all-cause or cardiac mortality. Method: This study utilised the Identifying Depression as a Comorbid Condition (IDACC) database of 337 hospitalised patients with AMI. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression scale (CES-D). Data were linked to a government administrative death registry to determine 5-year mortality. Survival data were analysed using Cox’s proportional hazards model. Results: The mean age during AMI hospitalisation was 59 years ± 12, 74% of patients were men and depression (CES-D ≥ 16) was present in 132 patients (39.3%). The 5-year all-cause mortality rate was 10.4% (35 deaths) and the cardiac mortality rate was 6.5% (22 deaths). When depression was defined as a dichotomous variable, moderate to severe depression (defined by CES-D ≥ 27) at the time of AMI was associated with all-cause mortality (hazard ratio 2.54, 95% confidence interval 1.03 to 6.28; p = 0.04) but not cardiac mortality. However, when depression was defined by three categories (no depression CES-D < 16, mild depression CES-D 16–26, moderate to severe depression CES-D ≥ 27), it was not found to predict mortality. In addition, perceived social support was a predictor of all-cause and cardiac mortality in AMI patients. Conclusions: Our results indicate that the relationship between mortality and depression severity is not linear and that the association only becomes evident when the severity reaches a threshold level of CES-D ≥ 27, consistent with major depression. Low power may have influenced the finding of a lack of association between depression and cardiac mortality. | - |
dc.description.statementofresponsibility | Alexis Wheeler, John Beltrame, Graeme Tucker, Tracy Air, Liang-Han Ling and Geoffrey Schrader | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Asia | - |
dc.rights | © The Royal Australian and New Zealand College of Psychiatrists 2012 | - |
dc.source.uri | http://dx.doi.org/10.1177/0004867412449875 | - |
dc.subject | Depression | - |
dc.subject | mortality | - |
dc.subject | myocardial infarction | - |
dc.title | Depression and 5-year mortality in patients with acute myocardial infarction: Analysis of the IDACC database | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1177/0004867412449875 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Beltrame, J. [0000-0002-4294-6510] | - |
dc.identifier.orcid | Tucker, G. [0000-0003-2621-5942] | - |
dc.identifier.orcid | Air, T. [0000-0002-4834-4238] | - |
dc.identifier.orcid | Schrader, G. [0000-0002-2504-8102] | - |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
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