Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72356
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Type: Journal article
Title: New therapeutic approaches to subarachnoid hemorrhage
Author: Barry, C.
Turner, R.
Corrigan, F.
Vink, R.
Citation: Expert Opinion on Investigational Drugs, 2012; 21(6):845-859
Publisher: Ashley Publications Ltd
Issue Date: 2012
ISSN: 1354-3784
1744-7658
Statement of
Responsibility: 
Christine Barry, Renee J Turner, Frances Corrigan & Robert Vink
Abstract: Introduction: Subarachnoid hemorrhage (SAH) is associated with significant morbidity and mortality, even for patients who receive early neurointerventionist management. Areas covered: Early mechanisms of secondary brain injury precede the delayed vasospasm phase and contribute to the poor outcome. These mechanisms and their intervention are discussed, including high intracranial pressure (ICP), low cerebral perfusion pressure (CPP), acute vasospasm, disturbed cerebral autoregulation, cerebral edema, oxidative stress, seizures, microvascular damage and hyperglycemia. Erythropoietin, statins and magnesium have been particularly promising in experimental studies. Expert opinion: Multiple mechanisms, including delayed vasospasm, may contribute to cerebral ischemia and poor outcome following SAH. Treatments that simultaneously target multiple secondary injury pathways show significant potential as therapeutic agents, particularly those that attenuate vasospasm in addition to having other neuroprotective properties.
Keywords: cerebral autoregulation; cerebral edema; cerebral perfusion; intracranial pressure; vasospasm
Rights: © 2012 Informa UK Ltd
RMID: 0020119126
DOI: 10.1517/13543784.2012.683113
Appears in Collections:Medical Sciences publications

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