Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia
Author: Zhou, S.
Yelland, L.
McPhee, A.
Quinlivan, J.
Gibson, R.
Makrides, M.
Citation: American Journal of Clinical Nutrition, 2012; 95(6):1378-1384
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2012
ISSN: 0002-9165
Statement of
Shao J. Zhou, Lisa Yelland, Andy J. McPhee, Julie Quinlivan, Robert A. Gibson and Maria Makrides
Abstract: BACKGROUND: There is uncertainty regarding the efficacy of increasing n23 long-chain PUFA (LCPUFA) intake during pregnancy in reducing the risk of gestational diabetes mellitus (GDM) and preeclampsia. OBJECTIVES: The objective was to determine whether n23 LCPUFA supplementation in pregnancy reduces the incidence of GDM or preeclampsia. A secondary objective was to assess the effect of n23 LCPUFA supplementation on perinatal complications. DESIGN: This was a double-blind, multicenter randomized control trial—the DHA to Optimize Mother Infant Outcome (DOMInO) trial. Pregnant women (n = 2399) of < 21 wk gestation were randomly assigned to receive DHA-enriched fish oil (800 mg/d) or vegetable oil capsules without DHA from trial entry to birth. The presence of GDM or preeclampsia was assessed through a blinded audit of medical records. Birth outcomes and prenatal complications were also assessed. RESULTS: The overall incidences of GDM and preeclampsia were 8% and 5%, respectively, based on clinical diagnosis. The RR of GDMwas 0.97 (95% CI: 0.74, 1.27)and of preeclampsia was 0.87 (95% CI: 0.60, 1.25),and they did not differ significantly between the groups. Birth weight, length, and head circumference z scores also did not differ between the groups. There were 12 perinatal deaths and 5 neonatal convulsions in the control group compared with 3 perinatal deaths and no neonatal convulsion in the DHA group (P = 0.03 in both cases). CONCLUSION: DHA supplementation of 800 mg/d in the second half of the pregnancy does not reduce the risk of GDM or preeclampsia. Whether supplementation reduces the risk of perinatal death and neonatal convulsions requires further investigation. The DOMInO trial was registered with the Australian New Zealand Clinical Trials Registry as TRN12605000569606.
Keywords: Humans
Diabetes, Gestational
Infant, Newborn, Diseases
Dietary Fats
Fatty Acids, Omega-3
Docosahexaenoic Acids
Fish Oils
Plant Oils
Pregnancy Outcome
Maternal Mortality
Double-Blind Method
Dietary Supplements
Infant, Newborn
Rights: © 2012 American Society for Nutrition
DOI: 10.3945/ajcn.111.033217
Appears in Collections:Aurora harvest
Paediatrics publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.