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Type: Journal article
Title: Selective serotonin reuptake inhibitors, Venlafaxine and Duloxetine are associated with in hospital morbidity but not bleeding or late mortality after coronary artery bypass graft surgery
Author: Tully, P.
Cardinal, T.
Bennetts, J.
Baker, R.
Citation: Heart, Lung & Circulation (Print Edition), 2012; 21(4):206-214
Publisher: Blackwell Publishing Asia
Issue Date: 2012
ISSN: 1443-9506
Statement of
Phillip J. Tully, Tess Cardinal, Jayme S. Bennetts, and Robert A. Baker
Abstract: <h4>Background</h4>No Australian study has reported the association between selective-serotonin reuptake inhibitor (SSRI) and serotonin noradrenaline reuptake inhibitor (SNRI) with coronary artery bypass graft (CABG) surgery morbidity and mortality.<h4>Methods</h4>4136 patients underwent CABG surgery between January 1996 and December 2008 and 105 (2.5%) were SSRI/SNRI users. Bleeding events included platelet, fresh frozen plasma and packed red blood cell transfusion, reoperation for bleeding and gastrointestinal bleeding. In-hospital morbidity included renal failure, stroke, ventilation >24h, deep sternal wound infection, reoperation (any cause), myocardial infarction and mortality.<h4>Results</h4>Median follow-up was 4.7 years (interquartile range, 2.3-7.9 years) and there were 727 deaths (17.6% of total). Use of SSRI/SNRI was associated with new requirement for renal dialysis (adjusted OR = 2.18; 95% CI, 1.06-4.45, p = .03) and ventilation >24h (adjusted OR = 1.69; 95% CI, 1.03-2.78, p = .04). Neither SSRI/SNRI use nor SSRI/SNRI and concomitant anti-platelet medication increased the odds for any bleeding events (all p>.20). No association was evident with all-cause mortality (adjusted hazard ratio = 1.60; 95% CI .59-4.35, p = .36), or cardiac mortality (adjusted hazard ratio = .31; 95% CI, .04-2.26, p = .25).<h4>Conclusions</h4>SSRI/SNRI users experienced an increased risk of renal dysfunction and prolonged ventilation, but not bleeding events or long-term mortality after CABG surgery.
Keywords: Coronary artery bypass; Antidepressive agents; Depression; Depressive disorder; Mortality; Morbidity
Rights: Crown copyright © 2012 Published by Elsevier Ltd. on behalf of The Australasian Society of Cardiac and Thoracic Surgeons and The Cardiac Society of Australia and New Zealand All rights reserved.
RMID: 0020117415
DOI: 10.1016/j.hlc.2011.12.002
Appears in Collections:Psychology publications

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