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Type: Journal article
Title: Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice
Author: Fullston, T.
Mc Pherson, N.
Owens, J.
Mitchell, M.
Bakos, H.
Lane, M.
Citation: Human Reproduction, 2012; 27(5):1391-1400
Publisher: Oxford Univ Press
Issue Date: 2012
ISSN: 0268-1161
Statement of
T. Fullston, N.O. Palmer, J.A. Owens, M. Mitchell, H.W. Bakos, and M. Lane
Abstract: BACKGROUND: Obesity and related conditions, notably subfertility, are increasingly prevalent. Paternal influences are known to influence offspring health outcome, but the impact of paternal obesity and subfertility on the reproductive health of subsequent generations has been overlooked. METHODS: A high-fat diet (HFD) was used to induce obesity but not diabetes in male C57Bl6 mice, which were subsequently mated to normal-weight females. First-generation offspring were raised on a control diet and their gametes were investigated for signs of subfertility. Second-generation offspring were generated from both first generation sexes and their gametes were similarly assessed. RESULTS: We demonstrate a HFD-induced paternal initiation of subfertility in both male and female offspring of two generations of mice. Furthermore, we have shown that diminished reproductive and gamete functions are transmitted through the first generation paternal line to both sexes of the second generation and via the first generation maternal line to second-generation males. Our previous findings that founder male obesity alters the epigenome of sperm, could provide a basis for the developmental programming of subfertility in subsequent generations. CONCLUSIONS: This is the first observation of paternal transmission of diminished reproductive health to future generations and could have significant implications for the transgenerational amplification of subfertility observed worldwide in humans.
Keywords: paternal obesity; fertilization; DNA damage; sperm quality; oocyte quality
Rights: © The Author 2012.
RMID: 0020118484
DOI: 10.1093/humrep/des030
Appears in Collections:Obstetrics and Gynaecology publications

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