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https://hdl.handle.net/2440/7267
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dc.contributor.author | Savino, M. | - |
dc.contributor.author | d'Apolito, M. | - |
dc.contributor.author | Centra, M. | - |
dc.contributor.author | van Beerendonk, H. | - |
dc.contributor.author | Cleton-Jansen, A.M. | - |
dc.contributor.author | Whitmore, S. | - |
dc.contributor.author | Crawford, J. | - |
dc.contributor.author | Callen, D. | - |
dc.contributor.author | Zelante, L. | - |
dc.contributor.author | Savoia, A. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Genomics, 1999; 61(2):219-226 | - |
dc.identifier.issn | 0888-7543 | - |
dc.identifier.issn | 1089-8646 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7267 | - |
dc.description | Copyright © 1999 Academic Press | - |
dc.description.abstract | In a search for candidate tumor suppressor genes within a 650-kb common region of loss of heterozygosity (LOH) at 16q24.3 in breast cancer tissues, a 2.6-kb cDNA, named copine VII (CPNE7), was characterized. The gene is 2654 bp and codes for a 633-residue protein with high homology to the other members of the copine family, such as copine I, copine III, and N-copine. The predicted amino acid sequence contains two copies of a C2 domain in the N-terminus. Since these domains have been found in several membrane-binding proteins involved in different intracellular processes, copine VII was viewed as a potential tumor suppressor gene. Mutation analysis was carried out by single-strand conformation polymorphism analysis of 18 breast tumor tissue samples with ascertained LOH on chromosome 16q24.3. Since only two polymorphisms were identified, no evidence was found to indicate that copine VII is the tumor suppressor gene at 16q24.3 involved in breast cancer. | - |
dc.description.statementofresponsibility | Maria Savino, Maria d'Apolito, Marta Centra, Hetty M. van Beerendonk, Anne-Marie Cleton-Jansen, Scott A. Whitmore, Joanna Crawford, David F. Callen, Leopoldo Zelante and Anna Savoia | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC | - |
dc.source.uri | http://dx.doi.org/10.1006/geno.1999.5958 | - |
dc.subject | Chromosomes, Human, Pair 16 | - |
dc.subject | Animals | - |
dc.subject | Humans | - |
dc.subject | Breast Neoplasms | - |
dc.subject | Membrane Proteins | - |
dc.subject | Sequence Alignment | - |
dc.subject | DNA Mutational Analysis | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Base Sequence | - |
dc.subject | Loss of Heterozygosity | - |
dc.subject | Polymorphism, Single-Stranded Conformational | - |
dc.subject | Genes, Tumor Suppressor | - |
dc.subject | Molecular Sequence Data | - |
dc.subject | Female | - |
dc.subject | Cricetinae | - |
dc.title | Characterization of copine VII, a new member of the copine family, and its exclusion as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1006/geno.1999.5958 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Callen, D. [0000-0002-6189-9991] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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