Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7274
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Type: Journal article
Title: TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma
Author: Rae, F.
Hooper, J.
Eyre, H.
Sutherland, G.
Nicol, D.
Clements, J.
Citation: Genomics, 2001; 77(3):200-207
Publisher: Academic Press Inc
Issue Date: 2001
ISSN: 0888-7543
1089-8646
Abstract: Using differential display PCR, we identified a novel gene upregulated in renal cell carcinoma. Characterization of the full-length cDNA and gene revealed that the encoded protein is a human homologue of the Drosophila melanogaster Tweety protein, and so we have termed the novel protein TTYH2. The orthologous mouse cDNA was also identified and the predicted mouse protein is 81% identical to the human protein. The encoded human TTYH2 protein is 534 amino acids and, like the other members of the tweety-related protein family, is a putative cell surface protein with five transmembrane regions. TTYH2 is located at 17q24; it is expressed most highly in brain and testis and at lower levels in heart, ovary, spleen, and peripheral blood leukocytes. Expression of this gene is upregulated in 13 of 16 (81%) renal cell carcinoma samples examined. In addition to a putative role in brain and testis, the over-expression of TTYH2 in renal cell carcinoma suggests that it may have an important role in kidney tumorigenesis.
Keywords: Testis
Brain
Chromosomes, Human, Pair 17
Animals
Humans
Mice
Drosophila melanogaster
Carcinoma, Renal Cell
Kidney Neoplasms
Membrane Proteins
Neoplasm Proteins
DNA, Complementary
In Situ Hybridization, Fluorescence
Chromosome Mapping
Gene Expression Profiling
Polymerase Chain Reaction
Sequence Alignment
Gene Expression Regulation, Neoplastic
Up-Regulation
Amino Acid Sequence
Molecular Sequence Data
Female
Male
DOI: 10.1006/geno.2001.6629
Published version: http://dx.doi.org/10.1006/geno.2001.6629
Appears in Collections:Aurora harvest 5
Paediatrics publications

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