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Type: Journal article
Title: TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma
Author: Rae, F.
Hooper, J.
Eyre, H.
Sutherland, G.
Nicol, D.
Clements, J.
Citation: Genomics, 2001; 77(3):200-207
Publisher: Academic Press Inc
Issue Date: 2001
ISSN: 0888-7543
Abstract: Using differential display PCR, we identified a novel gene upregulated in renal cell carcinoma. Characterization of the full-length cDNA and gene revealed that the encoded protein is a human homologue of the Drosophila melanogaster Tweety protein, and so we have termed the novel protein TTYH2. The orthologous mouse cDNA was also identified and the predicted mouse protein is 81% identical to the human protein. The encoded human TTYH2 protein is 534 amino acids and, like the other members of the tweety-related protein family, is a putative cell surface protein with five transmembrane regions. TTYH2 is located at 17q24; it is expressed most highly in brain and testis and at lower levels in heart, ovary, spleen, and peripheral blood leukocytes. Expression of this gene is upregulated in 13 of 16 (81%) renal cell carcinoma samples examined. In addition to a putative role in brain and testis, the over-expression of TTYH2 in renal cell carcinoma suggests that it may have an important role in kidney tumorigenesis.
Keywords: Testis; Brain; Chromosomes, Human, Pair 17; Animals; Humans; Mice; Drosophila melanogaster; Carcinoma, Renal Cell; Kidney Neoplasms; Membrane Proteins; Neoplasm Proteins; DNA, Complementary; In Situ Hybridization, Fluorescence; Chromosome Mapping; Gene Expression Profiling; Polymerase Chain Reaction; Sequence Alignment; Gene Expression Regulation, Neoplastic; Up-Regulation; Amino Acid Sequence; Molecular Sequence Data; Female; Male
RMID: 0020010903
DOI: 10.1006/geno.2001.6629
Appears in Collections:Paediatrics publications

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