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Type: Journal article
Title: Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: A novel gene family encoding predicted transmembrane proteins
Author: Campbell, H.
Kamei, M.
Claudianos, C.
Woollatt, E.
Sutherland, G.
Suzuki, Y.
Hida, M.
Sugano, S.
Young, I.
Citation: Genomics, 2000; 68(1):89-92
Publisher: Academic Press Inc Elsevier Science
Issue Date: 2000
ISSN: 0888-7543
Statement of
Campbell, Hugh D.; Kamei, Makoto; Claudianos, Charles; Woollatt, Erica; Sutherland, Grant R.; Suzuki, Yutaka; Hida, Munetomo; Sugano, Sumio; Young, Ian G.
Abstract: We have cloned cDNA for TTYH1, a human homologue of the Drosophila melanogaster tweety (tty) gene. The 450-residue predicted protein shows 27% amino acid sequence identity (51% similarity) to the Drosophila protein, which contains an additional C-terminal repetitive region. A second Drosophila homologue exhibits 42% identity (65% similarity) to the tty protein. Mouse (Ttyh1), macaque, and Caenorhabditis elegans homologues were also identified, and the complete coding sequence for the mouse gene was determined. The mouse protein is 91% identical to the human protein. Hydrophobicity analysis of the tty-related proteins indicates that they represent a new family of membrane proteins with five potential membrane-spanning regions. The yeast FTR1 and FTH1 iron transporter proteins and the mammalian neurotensin receptors 1 and 2 have a similar hydrophobicity profile, although there is no detectable sequence homology to the tty-related proteins. This suggests that the tweety-related proteins could be involved in transport of iron or other divalent cations or alternatively that they may be membrane-bound receptors. TTYH1 was mapped to chromosome 19q13.4 by FISH and by radiation hybrid mapping using the Stanford G3 panel.
Keywords: Hybrid Cells; Chromosomes, Human, Pair 19; Animals; Humans; Mice; Drosophila melanogaster; Insect Proteins; Membrane Proteins; DNA, Complementary; Chromosome Banding; In Situ Hybridization, Fluorescence; Chromosome Mapping; Sequence Alignment; Sequence Analysis, DNA; Phylogeny; Amino Acid Sequence; Sequence Homology, Amino Acid; Molecular Sequence Data; Cricetinae; Male
RMID: 0001000526
DOI: 10.1006/geno.2000.6259
Appears in Collections:Paediatrics publications

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