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Type: Journal article
Title: Human and mouse homologues of the Drosophila melanogaster tweety (tty) gene: A novel gene family encoding predicted transmembrane proteins
Author: Campbell, H.
Kamei, M.
Claudianos, C.
Woollatt, E.
Sutherland, G.
Suzuki, Y.
Hida, M.
Sugano, S.
Young, I.
Citation: Genomics, 2000; 68(1):89-92
Publisher: Academic Press Inc Elsevier Science
Issue Date: 2000
ISSN: 0888-7543
Statement of
Campbell, Hugh D.; Kamei, Makoto; Claudianos, Charles; Woollatt, Erica; Sutherland, Grant R.; Suzuki, Yutaka; Hida, Munetomo; Sugano, Sumio; Young, Ian G.
Abstract: We have cloned cDNA for TTYH1, a human homologue of the Drosophila melanogaster tweety (tty) gene. The 450-residue predicted protein shows 27% amino acid sequence identity (51% similarity) to the Drosophila protein, which contains an additional C-terminal repetitive region. A second Drosophila homologue exhibits 42% identity (65% similarity) to the tty protein. Mouse (Ttyh1), macaque, and Caenorhabditis elegans homologues were also identified, and the complete coding sequence for the mouse gene was determined. The mouse protein is 91% identical to the human protein. Hydrophobicity analysis of the tty-related proteins indicates that they represent a new family of membrane proteins with five potential membrane-spanning regions. The yeast FTR1 and FTH1 iron transporter proteins and the mammalian neurotensin receptors 1 and 2 have a similar hydrophobicity profile, although there is no detectable sequence homology to the tty-related proteins. This suggests that the tweety-related proteins could be involved in transport of iron or other divalent cations or alternatively that they may be membrane-bound receptors. TTYH1 was mapped to chromosome 19q13.4 by FISH and by radiation hybrid mapping using the Stanford G3 panel.
Keywords: Hybrid Cells
Chromosomes, Human, Pair 19
Drosophila melanogaster
Insect Proteins
Membrane Proteins
DNA, Complementary
Chromosome Banding
In Situ Hybridization, Fluorescence
Chromosome Mapping
Sequence Alignment
Sequence Analysis, DNA
Amino Acid Sequence
Sequence Homology, Amino Acid
Molecular Sequence Data
DOI: 10.1006/geno.2000.6259
Appears in Collections:Aurora harvest
Paediatrics publications

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