Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/72833
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dc.contributor.authorNicholson, I.-
dc.contributor.authorMavrangelos, C.-
dc.contributor.authorBird, D.-
dc.contributor.authorBresatz-Atkins, S.-
dc.contributor.authorEastaff-Leung, N.-
dc.contributor.authorGrose, R.-
dc.contributor.authorGundsambuu, B.-
dc.contributor.authorHill, D.-
dc.contributor.authorMillard, D.-
dc.contributor.authorSadlon, T.-
dc.contributor.authorTo, S.-
dc.contributor.authorZola, H.-
dc.contributor.authorBarry, S.-
dc.contributor.authorKrumbiegel, D.-
dc.date.issued2012-
dc.identifier.citationCellular Immunology, 2012; 275(1):12-18-
dc.identifier.issn0008-8749-
dc.identifier.issn1090-2163-
dc.identifier.urihttp://hdl.handle.net/2440/72833-
dc.description.abstractThe peptidase inhibitor PI16 was shown previously by microarray analysis to be over-expressed by CD4-positive/CD25-positive Treg compared with CD4-positive/CD25-negative Th cells. Using a monoclonal antibody to the human PI16 protein, we found that PI16-positive Treg have a memory (CD45RO-positive) phenotype and express higher levels of FOXP3 than PI16-negative Treg. PI16-positive Treg are functional in suppressor assays in vitro with potency similar to PI16-negative Treg. Further phenotyping of the PI16-positive Treg revealed that the chemokine receptors CCR4 and CCR6 are expressed by more of the PI16-positive/CD45RO-positive Treg compared with PI16-negative/CD45RO-positive Treg or Th cells. PI16-positive Treg showed enhanced in vitro migration towards the inflammatory chemokines CCL17 and CCL20, suggesting they can migrate to sites of inflammation. We conclude that PI16 identifies a novel distinct subset of functional memory Treg which can migrate to sites of inflammation and regulate the pro-inflammatory response at those sites.-
dc.description.statementofresponsibilityIan C. Nicholson, Christos Mavrangelos, Daniel R.G. Bird, Suzanne Bresatz-Atkins, Nicola G. Eastaff-Leung, Randall H. Grose, Batjargal Gundsambuu, Danika Hill, Debbrah J. Millard, Timothy J. Sadlon, Sarah To, Heddy Zola, Simon C. Barry, Doreen Krumbiegel-
dc.language.isoen-
dc.publisherAcademic Press Inc-
dc.rightsCopyright © 2012 Elsevier Inc. All rights reserved.-
dc.source.urihttp://dx.doi.org/10.1016/j.cellimm.2012.04.002-
dc.subjectRegulatory T cells-
dc.subjectLymphocyte migration-
dc.subjectMemory Treg-
dc.subjectPeptidase inhibitor 16-
dc.titlePI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20-
dc.typeJournal article-
dc.identifier.doi10.1016/j.cellimm.2012.04.002-
pubs.publication-statusPublished-
dc.identifier.orcidSadlon, T. [0000-0002-4821-2462]-
dc.identifier.orcidBarry, S. [0000-0002-0597-7609]-
Appears in Collections:Aurora harvest
Paediatrics publications

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