Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/72833
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nicholson, I. | - |
dc.contributor.author | Mavrangelos, C. | - |
dc.contributor.author | Bird, D. | - |
dc.contributor.author | Bresatz-Atkins, S. | - |
dc.contributor.author | Eastaff-Leung, N. | - |
dc.contributor.author | Grose, R. | - |
dc.contributor.author | Gundsambuu, B. | - |
dc.contributor.author | Hill, D. | - |
dc.contributor.author | Millard, D. | - |
dc.contributor.author | Sadlon, T. | - |
dc.contributor.author | To, S. | - |
dc.contributor.author | Zola, H. | - |
dc.contributor.author | Barry, S. | - |
dc.contributor.author | Krumbiegel, D. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Cellular Immunology, 2012; 275(1):12-18 | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.issn | 1090-2163 | - |
dc.identifier.uri | http://hdl.handle.net/2440/72833 | - |
dc.description.abstract | The peptidase inhibitor PI16 was shown previously by microarray analysis to be over-expressed by CD4-positive/CD25-positive Treg compared with CD4-positive/CD25-negative Th cells. Using a monoclonal antibody to the human PI16 protein, we found that PI16-positive Treg have a memory (CD45RO-positive) phenotype and express higher levels of FOXP3 than PI16-negative Treg. PI16-positive Treg are functional in suppressor assays in vitro with potency similar to PI16-negative Treg. Further phenotyping of the PI16-positive Treg revealed that the chemokine receptors CCR4 and CCR6 are expressed by more of the PI16-positive/CD45RO-positive Treg compared with PI16-negative/CD45RO-positive Treg or Th cells. PI16-positive Treg showed enhanced in vitro migration towards the inflammatory chemokines CCL17 and CCL20, suggesting they can migrate to sites of inflammation. We conclude that PI16 identifies a novel distinct subset of functional memory Treg which can migrate to sites of inflammation and regulate the pro-inflammatory response at those sites. | - |
dc.description.statementofresponsibility | Ian C. Nicholson, Christos Mavrangelos, Daniel R.G. Bird, Suzanne Bresatz-Atkins, Nicola G. Eastaff-Leung, Randall H. Grose, Batjargal Gundsambuu, Danika Hill, Debbrah J. Millard, Timothy J. Sadlon, Sarah To, Heddy Zola, Simon C. Barry, Doreen Krumbiegel | - |
dc.language.iso | en | - |
dc.publisher | Academic Press Inc | - |
dc.rights | Copyright © 2012 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.cellimm.2012.04.002 | - |
dc.subject | Regulatory T cells | - |
dc.subject | Lymphocyte migration | - |
dc.subject | Memory Treg | - |
dc.subject | Peptidase inhibitor 16 | - |
dc.title | PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.cellimm.2012.04.002 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Sadlon, T. [0000-0002-4821-2462] | - |
dc.identifier.orcid | Barry, S. [0000-0002-0597-7609] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_72833.pdf | Accepted version | 610.57 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.