Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Methylselenocysteine treatment leads to diselenide formation in human cancer cells: evidence from X-ray absorption spectroscopy studies
Author: Weekley, C.
Aitken, J.
Musgrave, I.
Harris, H.
Citation: Biochemistry, 2012; 51(3):736-738
Publisher: American Chemical Society
Issue Date: 2012
ISSN: 0006-2960
Statement of
Claire M. Weekley, Jade B. Aitken, Ian F. Musgrave, and Hugh H. Harris
Abstract: The selenoamino acids methylselenocysteine (MeSeCys) and selenomethionine (SeMet) have disparate efficacies as anticancer agents. Herein, we use X-ray absorption spectroscopy to determine the chemical form of selenium in human neuroblastoma cells. Cells treated with MeSeCys contain a significant diselenide component, which is absent from SeMet-treated cells and suggests that metabolites of MeSeCys are capable of altering the redox status of the cells. The differences in the speciation of Se in the selenoamino acid-treated cells may provide insight into the differing anticancer activities of MeSeCys and SeMet.
Keywords: Cell Line, Tumor; Humans; Selenium Compounds; Benzene Derivatives; Organoselenium Compounds; Selenocysteine; Cysteine; Antineoplastic Agents; X-Ray Absorption Spectroscopy
Rights: Copyright © 2012 American Chemical Society
RMID: 0020116830
DOI: 10.1021/bi201462u
Grant ID:
Appears in Collections:IPAS publications
Environment Institute publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.