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Type: Journal article
Title: Translational neuroprotection research in glaucoma: a review of definitions and principles
Author: Casson, R.
Chidlow, G.
Ebneter, A.
Wood, J.
Crowston, J.
Goldberg, I.
Citation: Clinical and Experimental Ophthalmology, 2012; 40(4):350-357
Publisher: Blackwell Publishing Asia
Issue Date: 2012
ISSN: 1442-6404
Statement of
Robert J Casson, Glyn Chidlow, Andreas Ebneter, John PM Wood, Jonathan Crowston and Ivan Goldberg
Abstract: The maintenance of vision, through prevention and attenuation of neuronal injury in glaucoma, forms the basis of current clinical practice. Currently, the reduction of intraocular pressure is the only proven method to achieve these goals. Although this strategy enjoys considerable success, some patients progress to blindness; hence, additional management options are highly desirable. Several terms describing treatment modalities of neuronal diseases with potential applicability to glaucoma are used in the literature, including neuroprotection, neurorecovery, neurorescue and neuroregeneration. These phenomena have not been defined within a coherent framework. Here, we suggest a set of definitions, postulates and principles to form a foundation for the successful translation of novel glaucoma therapies from the laboratory to the clinic.
Keywords: glaucoma; glaucoma medical therapy; glaucoma medication.
Rights: © 2011 The Authors
RMID: 0020120242
DOI: 10.1111/j.1442-9071.2011.02563.x
Appears in Collections:Opthalmology & Visual Sciences publications

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