Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72851
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Toll-like receptors in chronic pain
Author: Nicotra, L.
Loram, L.
Watkins, L.
Hutchinson, M.
Citation: Experimental Neurology, 2012; 234(2):316-329
Publisher: Academic Press Inc Elsevier Science
Issue Date: 2012
ISSN: 0014-4886
1090-2430
Statement of
Responsibility: 
Lauren Nicotra, Lisa C. Loram, Linda R. Watkins and Mark R. Hutchinson
Abstract: Proinflammatory central immune signaling contributes significantly to the initiation and maintenance of heightened pain states. Recent discoveries have implicated the innate immune system, pattern recognition Toll-like receptors in triggering these proinflammatory central immune signaling events. These exciting developments have been complemented by the discovery of neuronal expression of Toll-like receptors, suggesting pain pathways can be activated directly by the detection of pathogen associated molecular patterns or danger associated molecular patterns. This review will examine the evidence to date implicating Toll-like receptors and their associated signaling components in heightened pain states. In addition, insights into the impact Toll-like receptors have on priming central immune signaling systems for heightened pain states will be discussed. The influence possible sex differences in Toll-like receptor signaling have for female pain and the recognition of small molecule xenobiotics by Toll-like receptors will also be reviewed.
Keywords: Animals; Humans; Signal Transduction; Sex Characteristics; Female; Male; Toll-Like Receptors; Immunity, Innate; Chronic Pain; Nociception
Rights: Crown Copyright © 2011 Published by Elsevier Inc. All rights reserved.
RMID: 0020117448
DOI: 10.1016/j.expneurol.2011.09.038
Grant ID: http://purl.org/au-research/grants/arc/DP110100297
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.