Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7300
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Type: Journal article
Title: Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1
Author: Hort, Y.
Baker, E.
Sutherland, G.
Shine, J.
Herzog, H.
Citation: Genomics, 1995; 26(1):77-83
Publisher: Academic Press
Issue Date: 1995
ISSN: 0888-7543
1089-8646
Statement of
Responsibility: 
Yvonne Hort, Elizabeth Baker, Grant R. Sutherland, John Shine, Herbert Herzog
Abstract: Neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP) are structurally related but functionally diverse peptides, encoded by separate genes and expressed in different tissues. Although the human NPY gene has been mapped to chromosome 7, we demonstrate here that the genes for human PYY and PP (PPY) are localized only 10 kb apart from each other on chromosome 17q21.1. The high degree of homology between the members of this gene family, both in primary sequence and exon/intron structure, suggests that the NPY and the PYY genes arose from an initial gene duplication event, with a subsequent tandem duplication of the PYY gene being responsible for duplication of the PYY gene being responsible for the creation of the PPY gene. A second weaker hybridization signal also found on chromosome 17q11 and results obtained by Southern blot analysis suggest that the entire PYY-PPY region has undergone a further duplication event.
Keywords: Chromosomes, Human, Pair 17
Animals
Humans
Rats
Peptide YY
Pancreatic Polypeptide
Peptides
Neuropeptide Y
Blotting, Southern
In Situ Hybridization, Fluorescence
Chromosome Mapping
Cloning, Molecular
Sequence Alignment
Amino Acid Sequence
Regulatory Sequences, Nucleic Acid
TATA Box
Multigene Family
Exons
Molecular Sequence Data
DOI: 10.1016/0888-7543(95)80085-Z
Published version: http://dx.doi.org/10.1016/0888-7543(95)80085-z
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