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|Scopus||Web of Science®|
|Title:||Fluoroquinolone-resistant extraintestinal Escherichia coli clinical isolates representing the O15:K52:H1 clonal group from humans and dogs in Australia|
|Citation:||Comparative Immunology Microbiology and Infectious Diseases, 2012; 35(4):319-324|
|Publisher:||Pergamon-Elsevier Science Ltd|
|Joanne L. Platell, Rowland N. Cobbold, James R. Johnson, Connie R. Clabots, Darren J. Trott|
|Abstract:||Antimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) impact both human and veterinary medicine. One ExPEC clonal group that has become increasingly multidrug-resistant is serotype O15:K52:H1. Accordingly, we sought O15:K52:H1 strains among fluoroquinolone-resistant (FQ(r)) E. coli clinical isolates from humans (n=582) and dogs (n=120) in Australia. The phylogenetic group D isolates (267/702; 38%) were screened for O15:K52:H1-specific single-nucleotide polymorphisms (SNPs) in fumC and the O15 rfb variant. The 34 so-identified O15:K52:H1 isolates (33 human, 1 canine) underwent antimicrobial susceptibility profiling, virulence genotyping, and macrorestriction profiling. Although susceptibility profiles varied, the 34 isolates were closely related by pulsed-field gel electrophoresis and exhibited typical O15:K52:H1-associated virulence profiles (complete pap operon, F16 papA allele, papG allele II, iha, fimH, sat, fyuA, iutA, kpsMII, ompT). The canine isolate closely resembled human isolates. Thus, O15:K52:H1 strains contribute to the FQ(r) ExPEC population in Australia and may potentially be transferred between humans and dogs.|
|Keywords:||Extraintestinal pathogenic Escherichia coli; Fluoroquinolone resistance; Clonal group O15:K52:H1; Dogs|
|Rights:||Copyright © 2012 Elsevier Ltd.|
|Appears in Collections:||Animal and Veterinary Sciences publications|
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