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https://hdl.handle.net/2440/73054
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DC Field | Value | Language |
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dc.contributor.author | Platell, J. | - |
dc.contributor.author | Cobbold, R. | - |
dc.contributor.author | Johnson, J. | - |
dc.contributor.author | Clabots, C. | - |
dc.contributor.author | Trott, D. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Comparative Immunology, Microbiology and Infectious Diseases: the international journal for medical and veterinary researchers and practitioners, 2012; 35(4):319-324 | - |
dc.identifier.issn | 0147-9571 | - |
dc.identifier.issn | 1878-1667 | - |
dc.identifier.uri | http://hdl.handle.net/2440/73054 | - |
dc.description.abstract | Antimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) impact both human and veterinary medicine. One ExPEC clonal group that has become increasingly multidrug-resistant is serotype O15:K52:H1. Accordingly, we sought O15:K52:H1 strains among fluoroquinolone-resistant (FQ(r)) E. coli clinical isolates from humans (n=582) and dogs (n=120) in Australia. The phylogenetic group D isolates (267/702; 38%) were screened for O15:K52:H1-specific single-nucleotide polymorphisms (SNPs) in fumC and the O15 rfb variant. The 34 so-identified O15:K52:H1 isolates (33 human, 1 canine) underwent antimicrobial susceptibility profiling, virulence genotyping, and macrorestriction profiling. Although susceptibility profiles varied, the 34 isolates were closely related by pulsed-field gel electrophoresis and exhibited typical O15:K52:H1-associated virulence profiles (complete pap operon, F16 papA allele, papG allele II, iha, fimH, sat, fyuA, iutA, kpsMII, ompT). The canine isolate closely resembled human isolates. Thus, O15:K52:H1 strains contribute to the FQ(r) ExPEC population in Australia and may potentially be transferred between humans and dogs. | - |
dc.description.statementofresponsibility | Joanne L. Platell, Rowland N. Cobbold, James R. Johnson, Connie R. Clabots, Darren J. Trott | - |
dc.language.iso | en | - |
dc.publisher | Pergamon-Elsevier Science Ltd | - |
dc.rights | Copyright © 2012 Elsevier Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.cimid.2012.02.002 | - |
dc.subject | Extraintestinal pathogenic Escherichia coli | - |
dc.subject | Fluoroquinolone resistance | - |
dc.subject | Clonal group O15:K52:H1 | - |
dc.subject | Dogs | - |
dc.title | Fluoroquinolone-resistant extraintestinal Escherichia coli clinical isolates representing the O15:K52:H1 clonal group from humans and dogs in Australia | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.cimid.2012.02.002 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Trott, D. [0000-0002-8297-5770] | - |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 5 |
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