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dc.contributor.authorPlatell, J.-
dc.contributor.authorCobbold, R.-
dc.contributor.authorJohnson, J.-
dc.contributor.authorClabots, C.-
dc.contributor.authorTrott, D.-
dc.identifier.citationComparative Immunology, Microbiology and Infectious Diseases: the international journal for medical and veterinary researchers and practitioners, 2012; 35(4):319-324-
dc.description.abstractAntimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) impact both human and veterinary medicine. One ExPEC clonal group that has become increasingly multidrug-resistant is serotype O15:K52:H1. Accordingly, we sought O15:K52:H1 strains among fluoroquinolone-resistant (FQ(r)) E. coli clinical isolates from humans (n=582) and dogs (n=120) in Australia. The phylogenetic group D isolates (267/702; 38%) were screened for O15:K52:H1-specific single-nucleotide polymorphisms (SNPs) in fumC and the O15 rfb variant. The 34 so-identified O15:K52:H1 isolates (33 human, 1 canine) underwent antimicrobial susceptibility profiling, virulence genotyping, and macrorestriction profiling. Although susceptibility profiles varied, the 34 isolates were closely related by pulsed-field gel electrophoresis and exhibited typical O15:K52:H1-associated virulence profiles (complete pap operon, F16 papA allele, papG allele II, iha, fimH, sat, fyuA, iutA, kpsMII, ompT). The canine isolate closely resembled human isolates. Thus, O15:K52:H1 strains contribute to the FQ(r) ExPEC population in Australia and may potentially be transferred between humans and dogs.-
dc.description.statementofresponsibilityJoanne L. Platell, Rowland N. Cobbold, James R. Johnson, Connie R. Clabots, Darren J. Trott-
dc.publisherPergamon-Elsevier Science Ltd-
dc.rightsCopyright © 2012 Elsevier Ltd.-
dc.subjectExtraintestinal pathogenic Escherichia coli-
dc.subjectFluoroquinolone resistance-
dc.subjectClonal group O15:K52:H1-
dc.titleFluoroquinolone-resistant extraintestinal Escherichia coli clinical isolates representing the O15:K52:H1 clonal group from humans and dogs in Australia-
dc.typeJournal article-
dc.identifier.orcidTrott, D. [0000-0002-8297-5770]-
Appears in Collections:Animal and Veterinary Sciences publications
Aurora harvest 5

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