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dc.contributor.authorPlatell, J.en
dc.contributor.authorCobbold, R.en
dc.contributor.authorJohnson, J.en
dc.contributor.authorClabots, C.en
dc.contributor.authorTrott, D.en
dc.identifier.citationComparative Immunology Microbiology and Infectious Diseases, 2012; 35(4):319-324en
dc.description.abstractAntimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) impact both human and veterinary medicine. One ExPEC clonal group that has become increasingly multidrug-resistant is serotype O15:K52:H1. Accordingly, we sought O15:K52:H1 strains among fluoroquinolone-resistant (FQ(r)) E. coli clinical isolates from humans (n=582) and dogs (n=120) in Australia. The phylogenetic group D isolates (267/702; 38%) were screened for O15:K52:H1-specific single-nucleotide polymorphisms (SNPs) in fumC and the O15 rfb variant. The 34 so-identified O15:K52:H1 isolates (33 human, 1 canine) underwent antimicrobial susceptibility profiling, virulence genotyping, and macrorestriction profiling. Although susceptibility profiles varied, the 34 isolates were closely related by pulsed-field gel electrophoresis and exhibited typical O15:K52:H1-associated virulence profiles (complete pap operon, F16 papA allele, papG allele II, iha, fimH, sat, fyuA, iutA, kpsMII, ompT). The canine isolate closely resembled human isolates. Thus, O15:K52:H1 strains contribute to the FQ(r) ExPEC population in Australia and may potentially be transferred between humans and dogs.en
dc.description.statementofresponsibilityJoanne L. Platell, Rowland N. Cobbold, James R. Johnson, Connie R. Clabots, Darren J. Trotten
dc.publisherPergamon-Elsevier Science Ltden
dc.rightsCopyright © 2012 Elsevier Ltd.en
dc.subjectExtraintestinal pathogenic Escherichia coli; Fluoroquinolone resistance; Clonal group O15:K52:H1; Dogsen
dc.titleFluoroquinolone-resistant extraintestinal Escherichia coli clinical isolates representing the O15:K52:H1 clonal group from humans and dogs in Australiaen
dc.typeJournal articleen
pubs.library.collectionAnimal and Veterinary Sciences publicationsen
dc.identifier.orcidTrott, D. [0000-0002-8297-5770]en
Appears in Collections:Animal and Veterinary Sciences publications

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