Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7307
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Type: Journal article
Title: Insulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate
Author: Howarth, G.
Cool, J.
Bourne, A.
Ballard, F.
Read, L.
Citation: Growth Factors, 1998; 15(4):279-292
Publisher: HARWOOD ACAD PUBL GMBH
Issue Date: 1998
ISSN: 0897-7194
1029-2292
Abstract: <h4>Background</h4>We tested the ability of insulin-like growth factor-I (IGF-I) to reduce damage to the intestinal mucosa (mucositis) in rats injected with methotrexate. IGF-I was infused concurrent with methotrexate administration and compared to IGF-I administered following the withdrawal of methotrexate.<h4>Methods</h4>Rats were injected with methotrexate at the start of days 1, 2 and 3. IGF-I was infused for 5 days, commencing at the start of day 1 [concurrent administration] or at the start of day 4 [post-methotrexate administration].<h4>Results</h4>IGF-I administered coincident with methotrexate failed to restore mucosal integrity to the damaged small intestine. IGF-I administered post methotrexate stimulated regrowth of the damaged intestine, particularly the ileum, with 22%, 32% and 29% increases in small intestinal weight, ileal villus height and ileal crypt depth respectively.<h4>Conclusions</h4>Following intestinal damage of methotrexate, IGF-I primarily induced growth of the distal small intestine. The ineffectiveness of concurrently administered IGF-I may have represented an IGF-I induced recruitment of proliferating epithelial cells to the anti-proliferative effects of methotrexate.
Keywords: Intestinal Mucosa
Animals
Rats
Rats, Sprague-Dawley
Methotrexate
Sucrase
Insulin-Like Growth Factor I
Proteins
Insulin-Like Growth Factor Binding Proteins
DNA
Antimetabolites, Antineoplastic
Organ Size
Regeneration
Male
DOI: 10.3109/08977199809017483
Appears in Collections:Aurora harvest
Paediatrics publications

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