Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7307
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dc.contributor.authorHowarth, G.-
dc.contributor.authorCool, J.-
dc.contributor.authorBourne, A.-
dc.contributor.authorBallard, F.-
dc.contributor.authorRead, L.-
dc.date.issued1998-
dc.identifier.citationGrowth Factors, 1998; 15(4):279-292-
dc.identifier.issn0897-7194-
dc.identifier.issn1029-2292-
dc.identifier.urihttp://hdl.handle.net/2440/7307-
dc.description.abstract<h4>Background</h4>We tested the ability of insulin-like growth factor-I (IGF-I) to reduce damage to the intestinal mucosa (mucositis) in rats injected with methotrexate. IGF-I was infused concurrent with methotrexate administration and compared to IGF-I administered following the withdrawal of methotrexate.<h4>Methods</h4>Rats were injected with methotrexate at the start of days 1, 2 and 3. IGF-I was infused for 5 days, commencing at the start of day 1 [concurrent administration] or at the start of day 4 [post-methotrexate administration].<h4>Results</h4>IGF-I administered coincident with methotrexate failed to restore mucosal integrity to the damaged small intestine. IGF-I administered post methotrexate stimulated regrowth of the damaged intestine, particularly the ileum, with 22%, 32% and 29% increases in small intestinal weight, ileal villus height and ileal crypt depth respectively.<h4>Conclusions</h4>Following intestinal damage of methotrexate, IGF-I primarily induced growth of the distal small intestine. The ineffectiveness of concurrently administered IGF-I may have represented an IGF-I induced recruitment of proliferating epithelial cells to the anti-proliferative effects of methotrexate.-
dc.language.isoen-
dc.publisherHARWOOD ACAD PUBL GMBH-
dc.subjectIntestinal Mucosa-
dc.subjectAnimals-
dc.subjectRats-
dc.subjectRats, Sprague-Dawley-
dc.subjectMethotrexate-
dc.subjectSucrase-
dc.subjectInsulin-Like Growth Factor I-
dc.subjectProteins-
dc.subjectInsulin-Like Growth Factor Binding Proteins-
dc.subjectDNA-
dc.subjectAntimetabolites, Antineoplastic-
dc.subjectOrgan Size-
dc.subjectRegeneration-
dc.subjectMale-
dc.titleInsulin-like growth factor-I (IGF-I) stimulates regrowth of the damaged intestine in rats, when administered following, but not concurrent with, methotrexate-
dc.typeJournal article-
dc.identifier.doi10.3109/08977199809017483-
pubs.publication-statusPublished-
dc.identifier.orcidHowarth, G. [0000-0001-6979-6084]-
Appears in Collections:Aurora harvest
Paediatrics publications

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