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dc.contributor.authorTran, C.-
dc.contributor.authorHuynh, H.-
dc.contributor.authorvan den Berg, M.-
dc.contributor.authorvan der Pas, M.-
dc.contributor.authorCampbell, M.-
dc.contributor.authorPhilcox, J.-
dc.contributor.authorCoyle, P.-
dc.contributor.authorRofe, A.-
dc.contributor.authorButler, R.-
dc.identifier.citationHelicobacter (Oxford), 2003; 8(5):533-541-
dc.description.abstractBACKGROUND:Helicobacter pylori a primary cause of gastritis and peptic ulcer disease, is associated with increased production of reactive oxygen species within the gastric mucosa. Metallothionein (MT), a low-molecular-weight, cysteine-rich, metal-binding ligand, has been shown to sequester reactive oxygen species and reduce tissue damage. This study investigates the role of MT in H. pylori-induced gastritis in mice. MATERIALS AND METHODS:Control (MT+/+) and MT-null (MT-/-) mice were inoculated with either 1 x 108H. pylori or H. felis, and were infected for 4, 8 and 16 weeks or 8 weeks, respectively. H. pylori load was determined by culture. Myloperoxidase activity and MT levels were also determined. RESULTS:The stomachs of H. felis-infected mice were more severely inflamed than those of H. pylori-infected mice. H. felis-induced gastritis was more severe (p =.003) in MT-/- than in MT+/+ mice. MT-/- mice also had higher (60%; p <.05) H. pylori loads than MT+/+ mice 4 weeks after infection but not 8 or 16 weeks after infection. Myloperoxidase activity with H. pylori was similar between MT+/+ and MT-/- mice. Thirty-three per cent greater (p <.05) myloperoxidase activity was observed in MT-/- than in MT+/+ mice infected with H. felis. In MT+/+ mice infected with H. pylori, liver MT was increased by 33 and 39% (p <.05) at 8 and 16 weeks, respectively, whereas gastric MT increased by 46% (p <.05) at 4 weeks and declined to baseline levels at 8 and 16 weeks. CONCLUSIONS:Mice lacking MT are more susceptible to H. pylori colonization and gastric inflammation, indicating that MT may be protective against H. pylori-induced gastritis.-
dc.description.statementofresponsibilityCuong D. Tran, Hien Huynh, Maartje van den Berg, Mechtelt van der Pas, M. A. Fiona Campbell, Jeffrey C. Philcox, Peter Coyle, Allau M. Rofe and Ross N. Butler-
dc.publisherBlackwell Publishing Inc-
dc.rights© 2003 Blackwell Publishing Ltd-
dc.subjectGastric Mucosa-
dc.subjectMice, Knockout-
dc.subjectHelicobacter felis-
dc.subjectHelicobacter pylori-
dc.subjectHelicobacter Infections-
dc.subjectReactive Oxygen Species-
dc.subjectColony Count, Microbial-
dc.titleHelicobacter-induced gastritis in mice not expressing metallothionein-I and II-
dc.typeJournal article-
dc.identifier.orcidTran, C. [0000-0001-9220-2715]-
Appears in Collections:Aurora harvest
Paediatrics publications

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