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Type: Journal article
Title: Minireview: the androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?
Author: Hickey, T.
Robinson, J.
Carroll, J.
Tilley, W.
Citation: Molecular Endocrinology, 2012; 26(8):1252-1267
Publisher: Endocrine Soc
Issue Date: 2012
ISSN: 0888-8809
Statement of
T. E. Hickey, J. L. L. Robinson, J. S. Carroll, and W. D. Tilley
Abstract: Androgen receptor (AR) signaling exerts an antiestrogenic, growth-inhibitory influence in normal breast tissue, and this role may be sustained in estrogen receptor α (ERα)-positive luminal breast cancers. Conversely, AR signaling may promote growth of a subset of ERα-negative, AR-positive breast cancers with a molecular apocrine phenotype. Understanding the molecular mechanisms whereby androgens can elicit distinct gene expression programs and opposing proliferative responses in these two breast cancer phenotypes is critical to the development of new therapeutic strategies to target the AR in breast cancer.
Keywords: Mammary Glands, Human
Breast Neoplasms
Growth Inhibitors
Receptors, Androgen
Estrogen Receptor alpha
Signal Transduction
Genes, Tumor Suppressor
Rights: Copyright © 2012 by The Endocrine Society
DOI: 10.1210/me.2012-1107
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