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|Title:||Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children|
|Citation:||Human Immunology, 1999; 60(11):1039-1048|
|Publisher:||ELSEVIER SCIENCE INC|
|Abstract:||The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percentage of resting T cells expressed CD28 in neonates and young children compared to adults. CD28 expression was similar on adult and neonatal T cells activated with PMA and ionomycin. However, CD28 was expressed at greater intensity on a higher percentage of neonatal T cells than adult T cells stimulated with CD3. CD152 expression was lower on neonatal T cells than adult T cells stimulated with PMA and ionomycin and undetectable on neonatal T cells stimulated with CD3. In contrast, intracellular CD152 was equivalent in adult and neonatal T cells stimulated with PMA and ionomycin, suggesting trafficking of CD152 to the cell surface may be differentially regulated in neonatal T cells. Since the T cell response is determined by the balance of signals received from CD28 and CD152, high levels of CD28 expression and lower surface expression of CD152 on neonatal T cells may represent specialisation to promote activation of neonatal T cells.|
|Keywords:||B-Lymphocytes; Lymphocytes; T-Lymphocytes; Fetal Blood; Humans; Tetradecanoylphorbol Acetate; Ionomycin; Membrane Glycoproteins; Antigens, Differentiation; Antigens, CD; Immunoconjugates; Lymphocyte Activation; Adult; Infant; Infant, Newborn; CTLA-4 Antigen; In Vitro Techniques; Abatacept; CD3 Complex; CD28 Antigens; B7-1 Antigen; B7-2 Antigen|
|Appears in Collections:||Paediatrics publications|
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