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https://hdl.handle.net/2440/7338
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Type: | Journal article |
Title: | Interleukin 2 receptor regulation and IL-2 function in the human infant |
Author: | Zola, H. Ridings, J. Elliott, S. Nobbs, S. Weedon, H. Wheatland, L. Haslam, R. Roberton, D. Macardle, P. |
Citation: | Human Immunology, 1998; 59(10):615-624 |
Publisher: | Elsevier BV |
Issue Date: | 1998 |
ISSN: | 0198-8859 1879-1166 |
Abstract: | IL-2 receptor is expressed at low levels on adult blood lymphocytes, and at lower levels on cord blood cells. IL-2 receptor alpha and beta chain expression increases gradually from 0-18 months of age. The level of soluble CD25 (IL-2 receptor alpha chain) has been reported to be elevated in cord blood. Quantitative RT-PCR showed that adult cells express 10 times as much CD25 mRNA as cord cells. Cord plasma showed only a marginal ability to strip CD25 from the membrane. To assess the functional consequences of low IL-2 receptor expression, cord and adult cells were activated in vitro. The response was stimulus-dependent, but cord cells upregulated CD25 readily. Cord and adult cells proliferated in an IL-2-dependent assay to a similar extent. Infants suffering acute infection showed marginally higher levels of membrane CD25 expression than infants without overt infection. Thus neonatal and infant lymphocytes express lower levels of IL-2 receptors than adult cells, reflecting lower mRNA concentrations at least for CD25; they are able to up-regulate receptors in response to in vitro stimulation and are able to respond in vitro to IL-2-dependent stimulation; however in vivo there may be a dampening down of the IL-2 system in infancy. |
Keywords: | Leukocytes, Mononuclear Fetal Blood Humans Communicable Diseases Receptors, Interleukin-2 RNA, Messenger Interleukin-2 Lymphocyte Activation Age Factors Down-Regulation Up-Regulation Adult Infant Infant, Newborn Infections |
DOI: | 10.1016/S0198-8859(98)00069-X |
Published version: | http://dx.doi.org/10.1016/s0198-8859(98)00069-x |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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