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Type: Journal article
Title: Interleukin 2 receptor regulation and IL-2 function in the human infant
Author: Zola, H.
Ridings, J.
Elliott, S.
Nobbs, S.
Weedon, H.
Wheatland, L.
Haslam, R.
Roberton, D.
Macardle, P.
Citation: Human Immunology, 1998; 59(10):615-624
Publisher: Elsevier BV
Issue Date: 1998
ISSN: 0198-8859
Abstract: IL-2 receptor is expressed at low levels on adult blood lymphocytes, and at lower levels on cord blood cells. IL-2 receptor alpha and beta chain expression increases gradually from 0-18 months of age. The level of soluble CD25 (IL-2 receptor alpha chain) has been reported to be elevated in cord blood. Quantitative RT-PCR showed that adult cells express 10 times as much CD25 mRNA as cord cells. Cord plasma showed only a marginal ability to strip CD25 from the membrane. To assess the functional consequences of low IL-2 receptor expression, cord and adult cells were activated in vitro. The response was stimulus-dependent, but cord cells upregulated CD25 readily. Cord and adult cells proliferated in an IL-2-dependent assay to a similar extent. Infants suffering acute infection showed marginally higher levels of membrane CD25 expression than infants without overt infection. Thus neonatal and infant lymphocytes express lower levels of IL-2 receptors than adult cells, reflecting lower mRNA concentrations at least for CD25; they are able to up-regulate receptors in response to in vitro stimulation and are able to respond in vitro to IL-2-dependent stimulation; however in vivo there may be a dampening down of the IL-2 system in infancy.
Keywords: Leukocytes, Mononuclear; Fetal Blood; Humans; Communicable Diseases; Receptors, Interleukin-2; RNA, Messenger; Interleukin-2; Lymphocyte Activation; Age Factors; Down-Regulation; Up-Regulation; Adult; Infant; Infant, Newborn; Infections
RMID: 0030005608
DOI: 10.1016/S0198-8859(98)00069-X
Appears in Collections:Paediatrics publications

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