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https://hdl.handle.net/2440/7338
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dc.contributor.author | Zola, H. | - |
dc.contributor.author | Ridings, J. | - |
dc.contributor.author | Elliott, S. | - |
dc.contributor.author | Nobbs, S. | - |
dc.contributor.author | Weedon, H. | - |
dc.contributor.author | Wheatland, L. | - |
dc.contributor.author | Haslam, R. | - |
dc.contributor.author | Roberton, D. | - |
dc.contributor.author | Macardle, P. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Human Immunology, 1998; 59(10):615-624 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.issn | 1879-1166 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7338 | - |
dc.description.abstract | IL-2 receptor is expressed at low levels on adult blood lymphocytes, and at lower levels on cord blood cells. IL-2 receptor alpha and beta chain expression increases gradually from 0-18 months of age. The level of soluble CD25 (IL-2 receptor alpha chain) has been reported to be elevated in cord blood. Quantitative RT-PCR showed that adult cells express 10 times as much CD25 mRNA as cord cells. Cord plasma showed only a marginal ability to strip CD25 from the membrane. To assess the functional consequences of low IL-2 receptor expression, cord and adult cells were activated in vitro. The response was stimulus-dependent, but cord cells upregulated CD25 readily. Cord and adult cells proliferated in an IL-2-dependent assay to a similar extent. Infants suffering acute infection showed marginally higher levels of membrane CD25 expression than infants without overt infection. Thus neonatal and infant lymphocytes express lower levels of IL-2 receptors than adult cells, reflecting lower mRNA concentrations at least for CD25; they are able to up-regulate receptors in response to in vitro stimulation and are able to respond in vitro to IL-2-dependent stimulation; however in vivo there may be a dampening down of the IL-2 system in infancy. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.source.uri | http://dx.doi.org/10.1016/s0198-8859(98)00069-x | - |
dc.subject | Leukocytes, Mononuclear | - |
dc.subject | Fetal Blood | - |
dc.subject | Humans | - |
dc.subject | Communicable Diseases | - |
dc.subject | Receptors, Interleukin-2 | - |
dc.subject | RNA, Messenger | - |
dc.subject | Interleukin-2 | - |
dc.subject | Lymphocyte Activation | - |
dc.subject | Age Factors | - |
dc.subject | Down-Regulation | - |
dc.subject | Up-Regulation | - |
dc.subject | Adult | - |
dc.subject | Infant | - |
dc.subject | Infant, Newborn | - |
dc.subject | Infections | - |
dc.title | Interleukin 2 receptor regulation and IL-2 function in the human infant | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0198-8859(98)00069-X | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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