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Type: Journal article
Title: The treatment of infertility in polycystic ovary syndrome: a brief update
Author: Costello, M.
Misso, M.
Wong, J.
Hart, R.
Rombauts, L.
Melder, A.
Norman, R.
Teede, H.
Citation: Australian and New Zealand Journal of Obstetrics and Gynaecology, 2012; 52(4):400-403
Publisher: Blackwell Publishing Asia
Issue Date: 2012
ISSN: 0004-8666
Statement of
Michael F. Costello, Marie L. Misso, Jennifer Wong, Roger Hart, Luk Rombauts, Angela Melder, Robert J. Norman and Helen J. Teede
Abstract: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility. Lifestyle change alone is considered the first-line treatment for the management of infertile anovulatory PCOS women who are overweight or obese. First-line medical ovulation induction therapy to improve fertility outcomes is clomiphene citrate, whilst gonadotrophins, laparoscopic ovarian surgery or possibly metformin are second line in clomiphene citrate-resistant PCOS women. There is currently insufficient evidence to recommend aromatase inhibitors over that of clomiphene citrate in infertile anovulatory PCOS women in general or specifically in therapy naive or clomiphene citrate-resistant PCOS women. IVF/ICSI treatment is recommended either as a third-line treatment or in the presence of other infertility factors.
Keywords: Infertility
polycystic ovary syndrome
Rights: © 2012 The Authors ANZJOG © 2012 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists
DOI: 10.1111/j.1479-828X.2012.01448.x
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