Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/73522
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Type: Journal article
Title: Fluid outflow in a large-animal model of posttraumatic syringomyelia
Author: Wong, J.
Hemley, S.
Jones, N.
Cheng, S.
Bilston, L.
Stoodley, M.
Citation: Neurosurgery, 2012; 71(2):474-480
Publisher: Lippincott Williams & Wilkins
Issue Date: 2012
ISSN: 0148-396X
1524-4040
Statement of
Responsibility: 
Johnny Wong, Sarah Hemley, Nigel Jones, Shaokoon Cheng, Lynne Bilston, Marcus Stoodley
Abstract: <h4>Background</h4>Posttraumatic syringomyelia affects approximately 28% of spinal cord injury patients, and current treatments are often ineffective. The pathogenesis of this condition remains poorly understood. Previous reports have focused on pathways and mechanisms of fluid inflow; however, disturbances of fluid outflow mechanisms and pathways may be important in syrinx formation and enlargement.<h4>Objective</h4>To determine the route of fluid outflow from a syrinx in an animal model of posttraumatic syringomyelia.<h4>Methods</h4>A model of posttraumatic syringomyelia using excitotoxic amino acid and kaolin-induced arachnoiditis was created in 12 Merino wethers. Six weeks after syrinx induction, the cavities were localized and a cerebrospinal fluid tracer, horseradish peroxidase (HRP), was injected into the syrinx under ultrasonic guidance. After 10 minutes, the animals were killed and the spinal cords harvested for microscopy.<h4>Results</h4>An extracanalicular syrinx developed in 6 of the 12 sheep. HRP was successfully injected into 5 of the 6 syrinx cavities. HRP reaction product was observed in gray and white matter adjacent to the syrinx in a diffuse pattern. There were moderate amounts of HRP around the central canal and perivascular spaces and minimal amounts in the dorsal subarachnoid space.<h4>Conclusion</h4>In this model of posttraumatic syringomyelia, fluid outflow occurred in a diffuse manner into the surrounding extracellular space and toward the central canal and perivascular spaces. Fluid outflow may be an important consideration in the pathogenesis of syringomyelia and the development of new therapies.
Keywords: Animal model
Cerebrospinal fluid
Posttraumatic myelopathy
Syringomyelia
Rights: Copyright © by the Congress of Neurological Surgeons
DOI: 10.1227/NEU.0b013e31825927d6
Published version: http://dx.doi.org/10.1227/neu.0b013e31825927d6
Appears in Collections:Aurora harvest 5
Surgery publications

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