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Type: Journal article
Title: Polymer micelles for delayed release of therapeutics from drug-releasing surfaces with nanotubular structures
Author: Aw, M.
Addai-Mensah, J.
Losic, D.
Citation: Macromolecular Bioscience, 2012; 12(8):1048-1052
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
Issue Date: 2012
ISSN: 1616-5187
Statement of
Moom Sinn Aw, Jonas Addai-Mensah, Dusan Losic
Abstract: A new approach to engineer a local drug delivery system with delayed release using nanostructured surface with nanotube arrays is presented. TNT arrays electrochemically generated on a titanium surface are used as a model substrate. Polymer micelles as drug carriers encapsulated with drug are loaded at the bottom of the TNT structure and their delayed release is obtained by loading blank micelles (without drug) on the top. The delayed and time-controlled drug release is successfully demonstrated by controlling the ratio of blank and drug loaded-micelles. The concept is verified using four different polymer micelles (regular and inverted) loaded with water-insoluble (indomethacin) and water-soluble drugs (gentamicin).
Keywords: delayed drug release; drug-carriers; gentamicin; indomethacin; titania nanotubes
Rights: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
RMID: 0020121484
DOI: 10.1002/mabi.201200012
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Appears in Collections:Chemical Engineering publications

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