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|Title:||Molecular basis of p(CCG)n repeat instability at the FRA16A fragile site locus|
|Citation:||Human Molecular Genetics, 1995; 4(3):367-372|
|Nancarrow, J K ; Holman, K ; Mangelsdorf, M ; Hori, T ; Denton, M ; Sutherland, G R ; Richards, R I|
|Abstract:||Rare, folate-sensitive fragile sites are the result of the unstable expansion of trinucleotide p(CCG)n repeats, which are normally polymorphic in copy number. Differences in the number and frequency of alleles of the fragile site FRA16A p(CCG)n repeat were observed between different ethnic populations suggesting that certain alleles might be predisposed to instability. Sequence analysis demonstrated that the longer and more variable alleles were associated with loss of repeat interruption. Perfect repeat configuration therefore appears to be a necessary precondition for the instability associated with fragile site genesis.|
|Keywords:||Chromosomes, Human; Humans; Chromosome Fragility; Folic Acid; Polymerase Chain Reaction; Sequence Analysis, DNA; Base Sequence; Repetitive Sequences, Nucleic Acid; Gene Frequency; Alleles; Chromosome Fragile Sites; Models, Genetic; Molecular Sequence Data; Asian Continental Ancestry Group; European Continental Ancestry Group; Female; Male|
|Appears in Collections:||Paediatrics publications|
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