Adelaide Research & Scholarship
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https://hdl.handle.net/2440/73561
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| Type: | Journal article |
| Title: | Rare protein sequence variation in SV2A gene does not affect response to levetiracetam |
| Author: | Dibbens, L. Hodgson, B. Helbig, K. Oliver, K. Mulley, J. Berkovic, S. Scheffer, I. |
| Citation: | Epilepsy Research, 2012; 101(3):277-279 |
| Publisher: | Elsevier Science BV |
| Issue Date: | 2012 |
| ISSN: | 0920-1211 1872-6844 |
| Statement of Responsibility: | Leanne M. Dibbens, Bree L. Hodgson, Katherine L. Helbig, Karen L. Oliver, John C. Mulley, Samuel F. Berkovic, Ingrid E. Scheffer |
| Abstract: | Levetiracetam, a broad spectrum antiepileptic drug, binds to membrane protein SV2A. The protein coding region of SV2A was sequenced in 158 patients with focal or generalized epilepsies divided into three groups based on their response to levetiracetam: responders (>75% decrease), exacerbators (50% increase) and non-responders. Nonsynonymous coding variation within SV2A was extremely rare, suggesting that rare variation is not likely to account for the individual differences in response to levetiracetam. |
| Keywords: | SV2A Levetiracetam Epilepsy Genetics Pharmacogenetics |
| Rights: | © 2012 Elsevier B.V. All rights reserved. |
| DOI: | 10.1016/j.eplepsyres.2012.04.007 |
| Published version: | http://dx.doi.org/10.1016/j.eplepsyres.2012.04.007 |
| Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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