Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Rare protein sequence variation in SV2A gene does not affect response to levetiracetam|
|Citation:||Epilepsy Research, 2012; 101(3):277-279|
|Publisher:||Elsevier Science BV|
|Leanne M. Dibbens, Bree L. Hodgson, Katherine L. Helbig, Karen L. Oliver, John C. Mulley, Samuel F. Berkovic, Ingrid E. Scheffer|
|Abstract:||Levetiracetam, a broad spectrum antiepileptic drug, binds to membrane protein SV2A. The protein coding region of SV2A was sequenced in 158 patients with focal or generalized epilepsies divided into three groups based on their response to levetiracetam: responders (>75% decrease), exacerbators (50% increase) and non-responders. Nonsynonymous coding variation within SV2A was extremely rare, suggesting that rare variation is not likely to account for the individual differences in response to levetiracetam.|
|Keywords:||SV2A; Levetiracetam; Epilepsy; Genetics; Pharmacogenetics|
|Rights:||© 2012 Elsevier B.V. All rights reserved.|
|Appears in Collections:||Paediatrics publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.