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Type: Journal article
Title: Rare protein sequence variation in SV2A gene does not affect response to levetiracetam
Author: Dibbens, L.
Hodgson, B.
Helbig, K.
Oliver, K.
Mulley, J.
Berkovic, S.
Scheffer, I.
Citation: Epilepsy Research, 2012; 101(3):277-279
Publisher: Elsevier Science BV
Issue Date: 2012
ISSN: 0920-1211
Statement of
Leanne M. Dibbens, Bree L. Hodgson, Katherine L. Helbig, Karen L. Oliver, John C. Mulley, Samuel F. Berkovic, Ingrid E. Scheffer
Abstract: Levetiracetam, a broad spectrum antiepileptic drug, binds to membrane protein SV2A. The protein coding region of SV2A was sequenced in 158 patients with focal or generalized epilepsies divided into three groups based on their response to levetiracetam: responders (>75% decrease), exacerbators (50% increase) and non-responders. Nonsynonymous coding variation within SV2A was extremely rare, suggesting that rare variation is not likely to account for the individual differences in response to levetiracetam.
Keywords: SV2A; Levetiracetam; Epilepsy; Genetics; Pharmacogenetics
Rights: © 2012 Elsevier B.V. All rights reserved.
RMID: 0020121916
DOI: 10.1016/j.eplepsyres.2012.04.007
Appears in Collections:Paediatrics publications

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