Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73612
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Type: Journal article
Title: Intraduodenal protein modulates antropyloroduodenal motility, hormone release, glycemia, appetite, and energy intake in lean men
Author: Hutchison, A.
Feinle-Bisset, C.
Kallas, A.
Wishart, J.
Clifton, P.
Horowitz, M.
Luscombe-Marsh, N.
Citation: American Journal of Clinical Nutrition, 2012; 96(3):474-482
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2012
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Amy T. Ryan, Christine Feinle-Bisset, Asimina Kallas, Judith M. Wishart, Peter M. Clifton, Michael Horowitz and Natalie D. Luscombe-Marsh
Abstract: BACKGROUND: Intraduodenal fat and carbohydrate modulate antropyloroduodenal motility and hormone release and suppress appetite and energy intake in a load-dependent manner. Protein also suppresses energy intake, but its effects on these gastrointestinal factors and their role in the appetite-suppressive effects of protein remain unclear. OBJECTIVE: We aimed to characterize the effects of different intraduodenal protein loads on antropyloroduodenal pressures, gastrointestinal hormone release, glucose and insulin concentrations, appetite perceptions, and energy intake. DESIGN: Sixteen lean, healthy men were studied on 4 occasions in a randomized, double-blind fashion. Antropyloroduodenal pressures, plasma glucagon-like peptide 1 (GLP-1), cholecystokinin, peptide YY, ghrelin, blood glucose, serum insulin, and appetite were measured during 60-min, 4-mL/min intraduodenal infusions of protein at 0.5, 1.5, or 3 kcal/min or saline (control). Energy intakes at a buffet lunch consumed immediately after the infusion were quantified. RESULTS: Increases in the load of protein resulted in greater suppression of antral motility, greater stimulation of basal and isolated pyloric pressures and plasma cholecystokinin and GLP-1 concentrations, and greater suppression of energy intake. However, energy intake was reduced only after a protein load of 3 kcal/min compared with after all other treatments (P< 0.05). The suppression of energy intake after adjustment for cholecystokinin, GLP-1, and insulin was related inversely with basal pyloric pressure (r = 20.51, P < 0.001). CONCLUSION: The acute effects of intraduodenal protein on antropyloroduodenal motility, gastrointestinal hormone release, glucose, and insulin are load dependent and contribute to the suppression of energy intake.
Keywords: Duodenum; Pyloric Antrum; Humans; Gastrointestinal Hormones; Insulin; Blood Glucose; Dietary Proteins; Milk Proteins; Protein Hydrolysates; Cross-Over Studies; Double-Blind Method; Energy Intake; Appetite Regulation; Gastrointestinal Motility; Postprandial Period; Adult; Middle Aged; New Zealand; Male; Young Adult
Rights: © 2012 American Society for Nutrition
RMID: 0020121787
DOI: 10.3945/ajcn.112.038133
Appears in Collections:Medicine publications

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