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https://hdl.handle.net/2440/73661
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dc.contributor.author | Hong, Y. | - |
dc.contributor.author | Jeong, M. | - |
dc.contributor.author | Abizaid, A. | - |
dc.contributor.author | Banning, A. | - |
dc.contributor.author | Bartorelli, A. | - |
dc.contributor.author | Dzavik, V. | - |
dc.contributor.author | Ellis, S. | - |
dc.contributor.author | Gao, R. | - |
dc.contributor.author | Holmes, D. | - |
dc.contributor.author | Legrand, V. | - |
dc.contributor.author | Neumann, F. | - |
dc.contributor.author | Spaulding, C. | - |
dc.contributor.author | Worthley, S. | - |
dc.contributor.author | Urban, P. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | JACC: Cardiovascular Interventions, 2011; 4(9):982-991 | - |
dc.identifier.issn | 1936-8798 | - |
dc.identifier.issn | 1876-7605 | - |
dc.identifier.uri | http://hdl.handle.net/2440/73661 | - |
dc.description.abstract | <h4>Objectives</h4>The aim of this study was to identify the worldwide practice of Cypher Select (Cordis Corporation, Bridgewater, New Jersey) or Cypher Select Plus sirolimus-eluting stent (SES) in patients 80 years of age (octogenarian) and to identify clinical outcomes in this patient population.<h4>Background</h4>The use of drug-eluting stents in elderly patients may have different features compared with younger patients.<h4>Methods</h4>Between 2006 and 2008, 15,147 patients from 320 hospitals in 56 countries were enrolled in a registry. Initial implantation and follow-up outcome information obtained at 1-year follow-up in 675 octogenarian patients were compared with those in 14,472 nonoctogenarian patients.<h4>Results</h4>Octogenarians had significantly more comorbidities and had higher Charlson comorbidity index scores (1.5 ± 1.6 vs. 1.0 ± 1.3, p < 0.001). Rates of cardiac death (3.3% vs. 0.9%, p < 0.001), myocardial infarction (2.3% vs. 1.9%, p = 0.021), and definite or probable stent thrombosis (2.3% vs. 0.9%, p = 0.0002), and major bleeding (2.0% vs. 0.9%, p = 0.015) were significantly higher in octogenarians at 1 year; however, there was no significant difference in the rate of target lesion revascularization between the 2 groups (3.2% vs. 2.2%, p = 0.12). In octogenarians, a high Charlson comorbidity index was an independent predictor of death and stent thrombosis up to 360 days from the index procedure (hazard ratio: 1.3, 95% confidence interval: 1.1 to 1.5, p < 0.001, and hazard ratio: 1.5, 95% confidence interval: 1.3 to 1.8, p < 0.001, respectively).<h4>Conclusions</h4>Stenting with SES may be an effective therapeutic option in elderly patients, with acceptable rates of complications and a very low rate of repeat revascularization as demonstrated by this e-SELECT (A Multi-Center Post-Market Surveillance Registry) subgroup analysis. | - |
dc.description.statementofresponsibility | Young Joon Hong, Myung Ho Jeong, Alexander Abizaid, Adrian Banning, Antonio Bartorelli, Vladimir Dzavik, Stephen G. Ellis, Runlin Gao, David R. Holmes, Victor Legrand, Franz-Josef Neumann, Christian Spaulding, Stephen Worthley and Philip Urban | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Inc. | - |
dc.rights | © 2011 by the American College of Cardiology Foundation | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jcin.2011.06.013 | - |
dc.subject | e-SELECT Registry Investigators | - |
dc.subject | Humans | - |
dc.subject | Myocardial Infarction | - |
dc.subject | Thrombosis | - |
dc.subject | Sirolimus | - |
dc.subject | Cardiovascular Agents | - |
dc.subject | Fibrinolytic Agents | - |
dc.subject | Platelet Aggregation Inhibitors | - |
dc.subject | Treatment Outcome | - |
dc.subject | Registries | - |
dc.subject | Proportional Hazards Models | - |
dc.subject | Risk Assessment | - |
dc.subject | Risk Factors | - |
dc.subject | Prospective Studies | - |
dc.subject | Prosthesis Design | - |
dc.subject | Product Surveillance, Postmarketing | - |
dc.subject | Age Factors | - |
dc.subject | Patient Selection | - |
dc.subject | Time Factors | - |
dc.subject | Internet | - |
dc.subject | Aged | - |
dc.subject | Aged, 80 and over | - |
dc.subject | Middle Aged | - |
dc.subject | North America | - |
dc.subject | South America | - |
dc.subject | Australia | - |
dc.subject | Europe | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Drug-Eluting Stents | - |
dc.subject | Republic of Korea | - |
dc.subject | Angioplasty, Balloon, Coronary | - |
dc.subject | Kaplan-Meier Estimate | - |
dc.title | Sirolimus-eluting coronary stents in octogenarians: a 1-year analysis of the Worldwide e-SELECT Registry | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jcin.2011.06.013 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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