Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73720
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dc.contributor.authorPage, A.en
dc.contributor.authorSymonds, E.en
dc.contributor.authorPeiris, M.en
dc.contributor.authorBlackshaw, L.en
dc.contributor.authorYoung, R.en
dc.date.issued2012en
dc.identifier.citationBritish Journal of Pharmacology, 2012; 166(5):1537-1558en
dc.identifier.issn0007-1188en
dc.identifier.issn1476-5381en
dc.identifier.urihttp://hdl.handle.net/2440/73720-
dc.description.abstractInterest in pharmacological treatments for obesity that act in the brain to reduce appetite has increased exponentially over recent years, but failures of clinical trials and withdrawals due to adverse effects have so far precluded any success. Treatments that do not act within the brain are, in contrast, a neglected area of research and development. This is despite the fact that a vast wealth of molecular mechanisms exists within the gut epithelium and vagal afferent system that could be manipulated to increase satiety. Here we discuss mechano- and chemosensory pathways from the gut involved in appetite suppression, and distinguish between gastric and intestinal vagal afferent pathways in terms of their basic physiology and activation by enteroendocrine factors. Gastric bypass surgery makes use of this system by exposing areas of the intestine to greater nutrient loads resulting in greater satiety hormone release and reduced food intake. A non-surgical approach to this system is preferable for many reasons. This review details where the opportunities may lie for such approaches by describing nutrient-sensing mechanisms throughout the gastrointestinal tract.en
dc.description.statementofresponsibilityAmanda J Page, Erin Symonds, Madusha Peiris, L Ashley Blackshaw and Richard L Youngen
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.rights© 2012 The Authorsen
dc.subjectenteroendocrine cell; nutrient sensing; vagus nerve; obesityen
dc.titlePeripheral neural targets in obesityen
dc.typeJournal articleen
dc.identifier.rmid0020120473en
dc.identifier.doi10.1111/j.1476-5381.2012.01951.xen
dc.identifier.pubid23978-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidPage, A. [0000-0002-7086-5865]en
dc.identifier.orcidBlackshaw, L. [0000-0003-1565-0850]en
dc.identifier.orcidYoung, R. [0000-0001-5116-4951]en
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