Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/73834
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Type: Journal article
Title: Investigation of atrial vulnerability by analysis of the sinus node EG from atrial fibrillation models using a phase synchronization method
Author: Chen, Y.
Wu, Z.
Yang, C.
Shao, J.
Wong, K.
Abbott, D.
Citation: IEEE Transactions on Biomedical Engineering, 2012; 59(9):2668-2676
Publisher: IEEE-Inst Electrical Electronics Engineers Inc
Issue Date: 2012
ISSN: 0018-9294
1558-2531
Statement of
Responsibility: 
Ying Chen, Zhong Wu, Cuiwei Yang, Jun Shao, Kelvin Kian Loong Wong and Derek Abbott
Abstract: Atrial fibrillation (AF) can result in life-threatening arrhythmia, and a clinically convenient means for detecting vulnerability remains elusive. We investigated atrial vulnerability by analyzing the sinus electrogram (EG) from AF animal models using a phase synchronizationmethod. Using acetylcholine (ACh)-induced acute canine AF models (n= 4), a total of 128 electrical leads were attached to the surface of the anterior and posterior atria, and the pulmonary veins to form an electrocardiological mapping system. ACh was injected at varying concentrations with ladder-type adjustments. Sinus EGs and induced AF EGs that pertain to specific ACh concentrations were recorded.We hypothesize that the atrial vulnerability may be correlated with the Shannon entropy (SE) of the phase difference matrix that is extracted from the sinus EG. Our research suggests that the combination of SE with the synchronization method enables the sinus node EG to be analyzed and used to estimate atrial vulnerability. Index Terms—Atrial fibrillation (AF), electrophysiologicalmapping, phase synchronization, Shannon entropy, sinus rhythm.
Keywords: Atrial fibrillation (AF); electrophysiological mapping; phase synchronization; Shannon entropy; sinus rhythm
Rights: © 2012 IEEE
RMID: 0020122301
DOI: 10.1109/TBME.2012.2208751
Appears in Collections:Electrical and Electronic Engineering publications

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