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Type: Journal article
Title: Status of clomiphene citrate and metformin for infertility in PCOS
Author: Misso, M.
Teede, H.
Hart, R.
Wong, J.
Rombauts, L.
Melder, A.
Norman, R.
Costello, M.
Citation: Trends in Endocrinology and Metabolism, 2012; 23(10):533-543
Publisher: Elsevier Science London
Issue Date: 2012
ISSN: 1043-2760
Statement of
Marie L. Misso, Helena J. Teede, Roger Hart, Jennifer Wong, Luk Rombauts, Angela M. Melder, Robert J. Norman and Michael F. Costello
Abstract: Though widely used, there is uncertainty about the effectiveness and adverse effects of metformin and clomiphene citrate (CC) for infertility in polycystic ovary syndrome (PCOS). A systematic review (SR) of the best available evidence suggests that both CC and metformin are better than placebo for increasing ovulation and pregnancy rates, but CC is more effective than metformin for ovulation, pregnancy and live-birth rates, in PCOS patients with body mass index (BMI) >30. A combination of CC and metformin is superior to either metformin alone or CC alone, depending on the BMI and CC sensitivity of the patient. This SR provides key messages to guide clinicians and consumers on the use of these interventions in different subgroups of women with PCOS.
Keywords: Humans; Polycystic Ovary Syndrome; Infertility, Female; Metformin; Clomiphene; Ovulation Induction; Female
Rights: © 2012 Elsevier Ltd. All rights reserved.
RMID: 0020122120
DOI: 10.1016/j.tem.2012.07.001
Appears in Collections:Medical Sciences publications

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