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Type: Journal article
Title: Multiscale time irreversibility of heart rate and blood pressure variability during orthostasis
Author: Chladekova, L.
Czippelova, B.
Turianikova, Z.
Tonhajzerova, I.
Calkovska, A.
Baumert, M.
Javorka, M.
Citation: Physiological Measurement, 2012; 33(10):1747-1756
Publisher: IOP Publishing
Issue Date: 2012
ISSN: 0967-3334
Statement of
L. Chladekova, B. Czippelova, Z. Turianikova, I. Tonhajzerova, A. Calkovska, M. Baumert and M. Javorka
Abstract: Time irreversibility is a characteristic feature of non-equilibrium, complex systems such as the cardiovascular control mediated by the autonomic nervous system (ANS). Time irreversibility analysis of heart rate variability (HRV) and blood pressure variability (BPV) represents a new approach to assess cardiovascular regulatory mechanisms. The aim of this paper was to assess the changes in HRV and BPV irreversibility during the active orthostatic test (a balance of ANS shifted towards sympathetic predominance) in 28 healthy young subjects.We used three different time irreversibility indices— Porta’s, Guzik’s and Ehler’s indices (P%, G%and E, respectively) derived from data segments containing 1000 beat-to-beat intervals on four timescales. We observed an increase in the HRV and a decrease in the BPV irreversibility during standing compared to the supine position. The postural change in irreversibility was confirmed by surrogate data analysis. The differences were more evident in G% and E than P% and for higher scale factors. Statistical analysis showed a close relationship between G% and E. Contrary to this, the association between P% and G% and P% and E was not proven. We conclude that time irreversibility of beat-to-beat HRV and BPV is significantly altered during orthostasis, implicating involvement of the autonomous nervous system in its generation.
Keywords: Heart rate variability; blood pressure variability; time irreversibility; surrogate data; orthostatic challenge; sympathovagal balance
Rights: © 2012 Institute of Physics and Engineering in Medicine
RMID: 0020122116
DOI: 10.1088/0967-3334/33/10/1747
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Appears in Collections:Electrical and Electronic Engineering publications

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