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Type: Journal article
Title: The pertussis epidemic: informing strategies for prevention of severe disease
Author: Clarke, M.
Rasiah, K.
Copland, J.
Watson, M.
Koehler, A.
Dowling, K.
Marshall, H.
Citation: Epidemiology and Infection, 2013; 141(3):463-471
Publisher: Cambridge Univ Press
Issue Date: 2013
ISSN: 0950-2688
Statement of
M.F. Clark ; K. Rasiah ; J. Copland ; M. Watson ; A.P. Koehler ; K. Dowling and H. S. Marshall
Abstract: To assess the impact of Bordetella pertussis infections in South Australia during an epidemic and determine vulnerable populations, data from notification reports for pertussis cases occurring between July 2008 and December 2009 were reviewed to determine the distribution of disease according to specific risk factors and examine associations with hospitalizations. Although the majority (66%) of the 6230 notifications for pertussis occurred in adults aged >24 years, the highest notification and hospitalization rate occurred in infants aged <1 year. For these infants, factors associated with hospitalization included being aged <2 months [relative risk (RR) 2.3, 95% confidence interval (CI) 1.60–3.32], Indigenous ethnicity (RR 1.7, 95% CI 1.03–2.83) and receiving fewer than two doses of pertussis vaccine (RR 4.1, 95% CI 1.37–12.11). A combination of strategies aimed at improving direct protection for newborns, vaccination for the elderly, and reducing transmission from close contacts of infants are required for prevention of severe pertussis disease.
Keywords: Australia; epidemic; epidemiology; hospitalization; pertussis; prevention.
Rights: © Cambridge University Press 2012
RMID: 0020121608
DOI: 10.1017/S095026881200091X
Appears in Collections:Paediatrics publications

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