Adelaide Research & Scholarship
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https://hdl.handle.net/2440/7399
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| Type: | Journal article |
| Title: | The Role of Complement, Antibody, and Tumor Necrosis Factor Alpha in the Killing of Plasmodium Falciparum By the Monocytic Cell Line THP-1 |
| Author: | Kumaratilake, L. Ferrante, A. Jaeger, T. Morris-Jones, S. |
| Citation: | Infection and Immunity, 1997; 65(12):5342-5345 |
| Publisher: | AMER SOC MICROBIOLOGY |
| Issue Date: | 1997 |
| ISSN: | 0019-9567 1098-5522 |
| Abstract: | Killing of Plasmodium falciparum blood forms by the differentiated human myelomonocytic THP-1Mo cell line was studied by a radiometric assay. Results showed that parasite killing was promoted by complement, antimalarial antibody, and the cytokines tumor necrosis factor alpha and gamma interferon. Differentiated THP-1Mo appears to be a useful monocytic cell line for the study of mechanisms of immunity to Plasmodium. |
| Keywords: | Monocytes Cell Line Animals Humans Plasmodium falciparum Malaria, Falciparum Tumor Necrosis Factor-alpha Antibodies, Protozoan Cytotoxicity, Immunologic Complement System Proteins |
| DOI: | 10.1128/iai.65.12.5342-5345.1997 |
| Appears in Collections: | Aurora harvest Paediatrics publications |
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