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Type: Journal article
Title: The Role of Complement, Antibody, and Tumor Necrosis Factor Alpha in the Killing of Plasmodium Falciparum By the Monocytic Cell Line THP-1
Author: Kumaratilake, L.
Ferrante, A.
Jaeger, T.
Morris-Jones, S.
Citation: Infection and Immunity, 1997; 65(12):5342-5345
Issue Date: 1997
ISSN: 0019-9567
Abstract: Killing of Plasmodium falciparum blood forms by the differentiated human myelomonocytic THP-1Mo cell line was studied by a radiometric assay. Results showed that parasite killing was promoted by complement, antimalarial antibody, and the cytokines tumor necrosis factor alpha and gamma interferon. Differentiated THP-1Mo appears to be a useful monocytic cell line for the study of mechanisms of immunity to Plasmodium.
Keywords: Monocytes
Cell Line
Plasmodium falciparum
Malaria, Falciparum
Tumor Necrosis Factor-alpha
Antibodies, Protozoan
Cytotoxicity, Immunologic
Complement System Proteins
DOI: 10.1128/iai.65.12.5342-5345.1997
Appears in Collections:Aurora harvest
Paediatrics publications

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