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|Title:||Pharmacodynamics and dosing of aminoglycosides|
|Citation:||Infectious Disease Clinics of North America, 2003; 17(3):503-528|
|Publisher:||W B Saunders Co|
|Abstract:||Aminoglycosides are concentration-dependent killing agents whose pharmacodynamic predictors of efficacy are the area-under-the-curve to minimum inhibitory concentration ratio and the peak to minimum inhibitory concentration ratio. Prospective studies have shown that these agents can be given once-daily or less frequently in most clinical settings, with equal efficacy and possible reduced toxicity. Dosages for different clinical settings have been studied and methods are available to monitor once-daily dosing.|
|Keywords:||Animals; Humans; Gram-Negative Bacterial Infections; Hearing Loss; Kidney Diseases; Aminoglycosides; Area Under Curve; Tissue Distribution; Half-Life; Adult; Child; Female; Male|
|Appears in Collections:||Paediatrics publications|
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