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Type: Journal article
Title: Pharmacodynamics and dosing of aminoglycosides
Author: Turnidge, J.
Citation: Infectious Disease Clinics of North America, 2003; 17(3):503-528
Publisher: W B Saunders Co
Issue Date: 2003
ISSN: 0891-5520
Abstract: Aminoglycosides are concentration-dependent killing agents whose pharmacodynamic predictors of efficacy are the area-under-the-curve to minimum inhibitory concentration ratio and the peak to minimum inhibitory concentration ratio. Prospective studies have shown that these agents can be given once-daily or less frequently in most clinical settings, with equal efficacy and possible reduced toxicity. Dosages for different clinical settings have been studied and methods are available to monitor once-daily dosing.
Keywords: Animals; Humans; Gram-Negative Bacterial Infections; Hearing Loss; Kidney Diseases; Aminoglycosides; Area Under Curve; Tissue Distribution; Half-Life; Adult; Child; Female; Male
RMID: 0020031731
DOI: 10.1016/S0891-5520(03)00057-6
Appears in Collections:Paediatrics publications

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