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|Title:||The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro|
|Citation:||Inflammation Research, 2001; 50(4):213-219|
|Publisher:||Birkhauser Verlag Ag|
|Brand, C.; Ferrante, A.; Prager, R.H.; Riley, T.V.; Carson, C.F.; Finlay-Jones, J.J.; Hart, P.H.|
|Abstract:||<h4>Objective</h4>To evaluate the regulatory properties of the essential oil of Melaleuca alternifolia (tea tree oil) on the production of oxygen derived reactive species by human peripheral blood leukocytes activated in vitro.<h4>Materials and methods</h4>The ability of tea tree oil to reduce superoxide production by neutrophils and monocytes stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP), lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) was examined.<h4>Results</h4>The water-soluble fraction of tea tree oil had no significant effect on agonist-stimulated superoxide production by neutrophils, but significantly and dose-dependently suppressed agonist-stimulated superoxide production by monocytes. This suppression was not due to cell death. Chemical analysis identified the water-soluble components to be terpinen-4-ol, alpha-terpineol and 1,8-cineole. When examined individually, terpinen-4-ol significantly suppressed fMLP- and LPS- but not PMA-stimulated superoxide production; alpha-terpineol significantly suppressed fMLP-, LPS- and PMA-stimulated superoxide production; 1,8-cineole was without effect.<h4>Conclusion</h4>Tea tree oil components suppress the production of superoxide by monocytes, but not neutrophils, suggesting the potential for selective regulation of cell types by these components during inflammation.|
|Keywords:||Neutrophils; Monocytes; Cells, Cultured; Humans; Superoxides; Water; Cyclohexanols; Menthol; Terpenes; Tetradecanoylphorbol Acetate; Monoterpenes; Lipopolysaccharides; Tea Tree Oil; N-Formylmethionine Leucyl-Phenylalanine; Anti-Infective Agents, Local; Solubility; Cyclohexenes; Eucalyptol; Cyclohexane Monoterpenes|
|Appears in Collections:||Paediatrics publications|
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