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Type: Journal article
Title: Resistance development in community-acquired strains of methicillin-resistant Staphylococcus aureus: an in vitro study
Author: Munckhof, W.
Kleinschmidt, S.
Turnidge, J.
Citation: International Journal of Antimicrobial Agents, 2004; 24(6):605-608
Publisher: Elsevier Science BV
Issue Date: 2004
ISSN: 0924-8579
Abstract: This study compares in vitro antimicrobial resistance development between strains of Staphylococcus aureus including newly described community-acquired methicillin-resistant strains (CA-MRSA). High-level resistance developed in all strains of S. aureus after exposure to rifampicin and gentamicin and in some strains after fusidic acid exposure, independent of methicillin resistance phenotype. Resistance did not develop after exposure to clindamycin, cotrimoxazole, ciprofloxacin, linezolid, or vancomycin. These results have important implications for therapy of CA-MRSA infections.
Keywords: Humans; Staphylococcus aureus; Staphylococcal Infections; Community-Acquired Infections; Rifampin; Gentamicins; Microbial Sensitivity Tests; Prevalence; Methicillin Resistance; Drug Resistance, Multiple
RMID: 0020041364
DOI: 10.1016/j.ijantimicag.2004.08.009
Appears in Collections:Paediatrics publications

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