Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDonohoe, P.en
dc.contributor.authorHeddle, R.en
dc.contributor.authorSykes, P.en
dc.contributor.authorFusco, M.en
dc.contributor.authorFlego, L.en
dc.contributor.authorZola, H.en
dc.identifier.citationJournal of Allergy and Clinical Immunology, 1995; 95(2):587-596en
dc.description.abstractWe have analyzed IgE⁺ cells in peripheral blood of atopic donors, donors hypersensitive to bee venom, and nonatopic control donors with two- and three-color flow cytometry. Although the percentage of IgE⁺ cells varied among these groups, the overall phenotypic patterns were similar. Most IgE⁺ cells do not display typical B-cell markers, such as CD19, CD20, and CD21. A significant proportion of these cells stain for CD38, indicating that they are more differentiated. IgE⁺ cells express FcγRII and CD45RO, an isoform associated with an advanced level of differentiation. The majority of IgE⁺ cells do not coexpress other surface immunoglobulin isotypes. In the case of bee venom–hypersensitive donors, we have been able to identify a small population of IgE⁺ cells with a specificity for phospholipase A2, a major immunogenic component of bee venom. The phospholipase A2⁺ cells display a phenotype similar to that of the IgE+ cells.en
dc.description.statementofresponsibilityPeter J. Donohoe, Robert J. Heddle, Pamela J. Sykes, Michael Fusco, Loretta R. Flego, and Heddy Zolaen
dc.subjectbee venom hypersensitivity; desensitization; enumeration; IgE cell phenotype; immunotherapy mechanismen
dc.titleIgE+ cells in the peripheral blood of atopic, non-atopic and bee-venom hypersensitive individuals exhibit the phenotype of highly-differentiated B cellsen
dc.typeJournal articleen
Appears in Collections:Paediatrics publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.