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https://hdl.handle.net/2440/7427
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DC Field | Value | Language |
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dc.contributor.author | Bell, J. | - |
dc.contributor.author | Turnidge, J. | - |
dc.contributor.author | Ballow, C. | - |
dc.contributor.author | Jones, R. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Journal of Antimicrobial Chemotherapy, 2003; 51(2):339-345 | - |
dc.identifier.issn | 0305-7453 | - |
dc.identifier.issn | 1460-2091 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7427 | - |
dc.description.abstract | Multiresistance to antimicrobial agents is common in staphylococci and pneumococci isolates in the Western Pacific region. The activity of linezolid, a new oxazolidinone, was evaluated against a spectrum of Gram-positive species collected in the region. Eighteen laboratories from six countries in the Western Pacific examined the linezolid susceptibility of 2143 clinical isolates of Staphylococcus aureus, coagulase-negative staphylococci (CoNS) and Enterococcus spp. using broth microdilution or disc diffusion methodology. For Streptococcus pneumoniae (n = 351) and other streptococci (n = 83), Etest (AB Biodisk, Solna, Sweden) strips were used. Results were compared with other common and important antimicrobials. Linezolid-resistant strains were not detected among streptococci or staphylococci, including a significant proportion of S. aureus strains that were multiresistant. Almost all enterococci, including 14 vancomycin-resistant Enterococcus faecium, were linezolid susceptible. A small proportion of enterococci (0.8%) were intermediate to linezolid, and one strain of Enterococcus faecalis had a zone diameter of 20 mm (resistant). The linezolid MIC ranges (MIC(90)) of those strains tested by broth microdilution or Etest were: 1-4 mg/L (2 mg/L) for S. aureus, 0.5-4 mg/L (2 mg/L) for CoNS, 0.5-4 mg/L (2 mg/L) for Enterococcus spp., 0.12-2 mg/L (1 mg/L) for S. pneumoniae and 0.25-2 mg/L (1 mg/L) for Streptococcus spp. There was no difference in linezolid susceptibility between countries or between multiresistant and susceptible strains of each species monitored. | - |
dc.description.statementofresponsibility | Bell, Jan M; Turnidge, John D; Ballow, Charles H; Jones, Ronald N | - |
dc.language.iso | en | - |
dc.publisher | Oxford Univ Press | - |
dc.source.uri | http://dx.doi.org/10.1093/jac/dkg074 | - |
dc.subject | ZAPS Regional Participants | - |
dc.subject | Gram-Positive Bacteria | - |
dc.subject | Enterococcus faecalis | - |
dc.subject | Enterococcus faecium | - |
dc.subject | Streptococcus pneumoniae | - |
dc.subject | Gram-Positive Bacterial Infections | - |
dc.subject | Acetamides | - |
dc.subject | Oxazolidinones | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Microbial Sensitivity Tests | - |
dc.subject | Data Collection | - |
dc.subject | Drug Resistance, Bacterial | - |
dc.subject | Australia | - |
dc.subject | Linezolid | - |
dc.subject | Asia, Eastern | - |
dc.title | Multicentre evaluation of the in vitro activity of linezolid in the Western Pacific | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/jac/dkg074 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Turnidge, J. [0000-0003-4240-5578] | - |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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