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|Title:||The impact of maternal body mass index on the phenotype of pre-eclampsia: a prospective cohort study|
|Citation:||BJOG, 2012; 119(5):589-595|
|Publisher:||Blackwell Publishing Ltd|
|N.H. Anderson, L.M.E. McCowan, E.M. Fyfe, E.H.Y. Chan, R.S. Taylor, A.W. Stewart, G.A. Dekker and R.A. North on behalf of the SCOPE Consortium|
|Abstract:||OBJECTIVE: We hypothesised that among nulliparous women with pre-eclampsia, overweight or obese women would have a different phenotype of pre-eclampsia compared with normal weight women with pre-eclampsia. Specifically, they are more likely to develop term pre-eclampsia and less likely to have indicators of impaired placental perfusion, e.g. abnormal uterine artery Doppler or a small-for-gestational-age (SGA) infant. DESIGN: Prospective, multicentre, cohort SCOPE study (n = 3170). SETTING: New Zealand and Australia. POPULATION: Nulliparous women who developed pre-eclampsia. METHODS: Participants were interviewed at 14–16 weeks of gestation, uterine artery Doppler studies were performed at 19–21 weeks and pregnancy outcome was tracked prospectively. MAIN OUTCOME MEASURES: Rates of abnormal uterine artery Doppler indices, term/preterm birth and SGA infants were compared between normal, overweight and obese women with pre-eclampsia. Multivariable analysis was performed to examine the association between body mass index (BMI) and term preeclampsia. RESULTS: Of 178 women with pre-eclampsia, one underweight woman was excluded and 66 (37%) were normal weight, 52 (29%) were overweight and 59 (34%) were obese. Pre-eclampsia developed preterm in 26% of women and at term in 74% of women. There were no differences in the rates of term/preterm pre-eclampsia, abnormal uterine artery Doppler indices or SGA infants between BMI groups (P > 0.10). No independent association between BMI and term pre-eclampsia was found (P = 0.56). CONCLUSIONS: Among women with pre-eclampsia, those who are overweight or obese in early pregnancy are not more likely to have term pre-eclampsia compared with women with a normal BMI. Overweight and obese women require vigilant surveillance for the development of preterm as well as term pre-eclampsia.|
|Keywords:||Body mass index; obesity; overweight, pregnancy outcomes; preterm pre-eclampsia; small for gestational age; termpre-eclampsia|
|Rights:||© 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG|
|Appears in Collections:||Obstetrics and Gynaecology publications|
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