Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/74306
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Humpage, A. | - |
dc.contributor.author | Falconer, I. | - |
dc.contributor.author | Bernard, C. | - |
dc.contributor.author | Froscio, S. | - |
dc.contributor.author | Fabbro, L. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Water Research, 2012; 46(5):1576-1583 | - |
dc.identifier.issn | 0043-1354 | - |
dc.identifier.issn | 1879-2448 | - |
dc.identifier.uri | http://hdl.handle.net/2440/74306 | - |
dc.description.abstract | A growing list of freshwater cyanobacteria are known to produce toxic agents, a fact which makes these organisms of concern to water authorities. A cultured strain of Limnothrix (AC0243) was recently shown to have toxic effects in in vitro bioassays. It did not produce any of the known cyanobacterial toxins. The intrapertoneal toxicity of aqueous extracts of the material was therefore tested in mice to determine whether the observed effects might be of public health relevance to drinking water supplies. The results indicate that Limnothrix AC0243 is acutely toxic to mice, causing widespread cellular necrosis in the liver, kidneys and gastrointestinal tract within 24 h of exposure. Sub-lethal effects lasted at least 7 d. These results suggest that Limnothrix AC0243 produces a novel toxin ("Limnothrixin") and that further work is therefore urgently required to quantify the potential public health implications. | - |
dc.description.statementofresponsibility | Andrew Humpage, Ian Falconer, Catherine Bernard, Suzanne Froscio and Larelle Fabbro | - |
dc.language.iso | en | - |
dc.publisher | Pergamon-Elsevier Science Ltd | - |
dc.rights | © 2011 Elsevier Ltd. All rights reserved | - |
dc.source.uri | http://dx.doi.org/10.1016/j.watres.2011.11.019 | - |
dc.subject | Gastrointestinal Tract | - |
dc.subject | Liver | - |
dc.subject | Kidney | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Mice | - |
dc.subject | Cyanobacteria | - |
dc.subject | Necrosis | - |
dc.subject | Bacterial Toxins | - |
dc.subject | Marine Toxins | - |
dc.subject | Protein Biosynthesis | - |
dc.subject | Male | - |
dc.subject | Microcystins | - |
dc.subject | Cyanobacteria Toxins | - |
dc.title | Toxicity of the cyanobacterium Limnothrix AC0243 to male Balb/c mice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.watres.2011.11.019 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Falconer, I. [0000-0002-1444-2681] | - |
Appears in Collections: | Aurora harvest Environment Institute publications Pharmacology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.