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Type: Journal article
Title: Developmental perturbation induced by maternal asthma during pregnancy: The short- and long-term impacts on offspring
Author: Clifton, V.
Davies, M.
Moore, V.
Wright, I.
Ali, Z.
Hodyl, N.
Citation: Journal of Pregnancy, 2012; 2012:1-8
Publisher: Hindawi Publishing Corporation
Issue Date: 2012
ISSN: 2090-2727
Statement of
Vicki L. Clifton, Michael Davies, Vivienne Moore, Ian M. R. Wright, Zainab Ali, and Nicolette A. Hodyl
Abstract: Maternal asthma is a common disease to complicate human pregnancy. Epidemiological studies have identified that asthma during pregnancy increases the risk of a number of poor outcomes for the neonate including growth restriction, lower birthweight, preterm delivery, neonatal resuscitation, and stillbirth. Asthma therefore represents a significant health burden to society and could have an impact on the lifelong health of the children of women with asthma. Our research has identified that maternal asthma in pregnancy induces placental dysfunction and developmental perturbation in the fetus in a sex specific manner. These alterations in development could increase the risk of metabolic disease in adulthood of children of asthmatic mothers, especially females. In this paper, we will discuss the evidence currently available that supports the hypothesis that children of mothers with asthma may be at risk of lifelong health complications which include diabetes and hypertension.
Keywords: Mitochondria
Pregnancy Complications
Prenatal Exposure Delayed Effects
Metabolic Syndrome X
Growth Disorders
Sex Factors
Gene Expression Regulation, Developmental
Fetal Development
Vascular Resistance
Description: Extent: 8p.
Rights: Copyright © 2012 Vicki L. Clifton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1155/2012/741613
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Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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