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Type: Journal article
Title: IsomiRs - the overlooked repertoire in the dynamic microRNAome
Author: Neilsen, C.
Goodall, G.
Bracken, C.
Citation: Trends in Genetics, 2012; 28(11):544-549
Publisher: Elsevier Science London
Issue Date: 2012
ISSN: 0168-9525
Statement of
Corine T. Neilsen, Gregory J. Goodall and Cameron P. Bracken
Abstract: The development of deep sequencing has enabled the identification of novel microRNAs (miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be heterogeneous in length and/or sequence. These variants, termed isomiRs, can be expressed in a cell-specific manner, and numerous recent studies suggest that at least some isomiRs may affect target selection, miRNA stability, or loading into the RNA-induced silencing complex (RISC). Reports indicating differential functionality for isomiRs are currently confined to several specific variants, and although isomiRs are common, their broader biological significance is yet to be fully resolved. Here we review the growing body of evidence suggesting that isomiRs have functional differences, of which at least some appear biologically relevant, and caution researchers to take miRNA isoforms into consideration in their experiments.
Keywords: isomiR; microRNA isoform; microRNA sequence variant; 5′ and 3′ heterogeneity; RNA editing; microRNA polymorphism
Rights: © 2012 Elsevier Ltd. All rights reserved.
RMID: 0020122555
DOI: 10.1016/j.tig.2012.07.005
Appears in Collections:Genetics publications
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