Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/74502
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dc.contributor.authorDa Silva, J.en
dc.date.issued2012en
dc.identifier.citationEvolution, 2012; 66(10):3079-3087en
dc.identifier.issn0014-3820en
dc.identifier.issn1558-5646en
dc.identifier.urihttp://hdl.handle.net/2440/74502-
dc.description.abstractPathogens adapt to antibody surveillance through amino acid replacements in targeted protein regions, or epitopes, that interfere with antibody binding. However, such escape mutations may exact a fitness cost due to impaired protein function. Here, it is hypothesized that the recurring generation of specific neutralizing antibodies to an epitope region as it evolves in response to antibody selection will cause amino acid reversions by releasing early escape mutations from immune selection. The plausibility of this hypothesis was tested with stochastic simulation of adaptation at the molecular sequence level in finite populations. Under the conditions of strong selection and weak mutation, the rates of allele fixation and amino acid reversion increased with population size and selection coefficients. These rates decreased with population size, however, if mutation became strong, because clonal interference reduced the rate of adaptation. The model successfully predicts the rate of reversion per allele fixation for an important human immunodeficiency virus type 1 (HIV-1) antibody epitope region. Therefore, antibody selection may generate complex adaptive dynamics.en
dc.description.statementofresponsibilityJack da Silvaen
dc.language.isoenen
dc.publisherSoc Study Evolutionen
dc.rights© 2012 The Author(s). Evolution © 2012 The Society for the Study of Evolution.en
dc.subjectAmino acid reversion; antibody; epitope; escape mutation; HIVen
dc.titleAntibody selection and amino acid reversionsen
dc.typeJournal articleen
dc.identifier.rmid0020122387en
dc.identifier.doi10.1111/j.1558-5646.2012.01686.xen
dc.identifier.pubid22920-
pubs.library.collectionMolecular and Biomedical Science publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidDa Silva, J. [0000-0001-5631-5421]en
Appears in Collections:Molecular and Biomedical Science publications

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